An Evaluation of Different Strategies for Sampling Controls in an Online Case-Crossover Study of Acute Flares in Knee Osteoarthritis

Rathod-Mistry, Trishna; Peat, George; Neogi, Tuhina; Thomas, Martin J

Abstract

Objective: To evaluate bias and precision of exposure-outcome effect estimates from three control sampling strategies in a case-crossover study.
Methods: Online case-crossover study investigating eight physical activity-related triggers for acute flares in knee osteoarthritis. Exposures were measured in hazard periods (≤ 24 hours before self-declared flare onset). Control period exposure was measured in three ways: (1) four scheduled questionnaires over 13-weeks, (2) “usual” physical activity levels ascertained at baseline, (3) over three days before flare onset. Derived odds ratios, 95% confidence intervals and standard errors were compared.

• Journal Article Type: Article
• Acceptance Date: Apr 19, 2023
• Publication Date: May 16, 2023
• Deposit Date: May 25, 2023
• Journal: Clinical Epidemiology
• Print ISSN: 1179-1349
• Publisher: Dove Press
• Peer Reviewed: Peer Reviewed
• Volume: Volume 15
• Pages: 635-644
• DOI: https://doi.org/10.2147/clep.s401488
• Keywords: Epidemiology