Deciphering the ubiquitin-mediated pathway in apicomplexan parasites: a potential strategy to interfere with parasite virulence

Horrocks

Abstract

Reversible modification of proteins through the attachment of ubiquitin or ubiquitin-like modifiers is an essential post-translational regulatory mechanism in eukaryotes. The conjugation of ubiquitin or ubiquitin-like proteins has been demonstrated to play roles in growth, adaptation and homeostasis in all eukaryotes, with perturbation of ubiquitin-mediated systems associated with the pathogenesis of many human diseases, including cancer and neurodegenerative disorders.

Citation

Horrocks. (2008). Deciphering the ubiquitin-mediated pathway in apicomplexan parasites: a potential strategy to interfere with parasite virulence. PloS one, e2386 - ?. https://doi.org/10.1371/journal.pone.0002386

• Acceptance Date: Apr 24, 2008
• Publication Date: Apr 24, 2008
• Journal: PLoS One
• Print ISSN: 1932-6203
• Publisher: Public Library of Science
• Pages: e2386 - ?
• DOI: https://doi.org/10.1371/journal.pone.0002386
• Keywords: Apicomplexa, Plasmodium, Protein domains, Toxoplasma gondii, Ligases, Ubiquitin ligases, Cell cycle and cell division, Conjugated proteins