The influence of HLA-DRB1 alleles encoding the DERAA amino acid motif on radiological outcome in rheumatoid arthritis.

Abstract

To investigate the influence of HLA-DRB1 alleles encoding the QK/RRAA shared epitope (SE) on radiological outcome in rheumatoid arthritis (RA), and to determine whether it is modulated by alleles carrying the putative rheumatoid arthritis-protective (RAP) sequence DERAA. Patients and methods. The association between erosive damage and HLA-DRB1 status was examined in 315 RA patients with a disease duration of 5-30 yr. Radiological outcome was measured by scoring X-rays of the hands and feet using the standard radiographs of Larsen (Larsen score). HLA-DRB1 typing was carried out using polymerase chain reaction methodology.

Citation

(1999). The influence of HLA-DRB1 alleles encoding the DERAA amino acid motif on radiological outcome in rheumatoid arthritis. Rheumatology, 1221 - 1227. https://doi.org/10.1093/rheumatology/38.12.1221

• Acceptance Date: Jul 1, 1999
• Publication Date: Dec 1, 1999
• Journal: Rheumatology (Oxford)
• Print ISSN: 1462-0324
• Publisher: Oxford University Press
• Pages: 1221 - 1227
• DOI: https://doi.org/10.1093/rheumatology/38.12.1221
• Keywords: Rheumatoid arthritis, HLA-DRB1, Shared epitope, Protective alleles, Radiological outcome
• Publisher URL: http://rheumatology.oxfordjournals.org/content/38/12/1221.long