Outputs (2247)

Development, characterisation and application of a novel nanofiber-based 3D technique for isolation, enrichment and purification of extracellular vesicles from mesenchymal stem cells (2024)
Thesis
Alfred, K. I. Development, characterisation and application of a novel nanofiber-based 3D technique for isolation, enrichment and purification of extracellular vesicles from mesenchymal stem cells. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/1015802

Extracellular vesicles (EVs) are nanoscale, lipid-bound particles carrying bioactive molecules produced by cells. Mesenchymal stem cells (MSC) are preferred sources for producing therapeutically relevant EVs (MSC-EVs). Nonetheless, harnessing MSC-EVs... Read More about Development, characterisation and application of a novel nanofiber-based 3D technique for isolation, enrichment and purification of extracellular vesicles from mesenchymal stem cells.

Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model (2024)
Journal Article
Perry, J., Mennan, C., Cool, P., McCarthy, H., Newell, K., Hopkins, T., …Roberts, S. (2024). Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model. Cartilage, https://doi.org/10.1177/19476035241287832

Objective
To determine if mesenchymal stromal cells (MSCs) derived from human umbilical cords (hUC) could reduce degeneration developing when injected into the knee of a large animal model of osteoarthritis (OA).
Design
Ten million culture-expande... Read More about Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model.

125P A review of the management and outcomes of children with SMA in the West Midlands, UK during 2017-2022 (2024)
Journal Article
Willis, T., Kulshrestha, R., Alhaswani, Z., Parasuraman, D., Kuiper, J., Jones, J., & Perry, C. (2024). 125P A review of the management and outcomes of children with SMA in the West Midlands, UK during 2017-2022. Neuromuscular Disorders, 43, Article 104441.23. https://doi.org/10.1016/j.nmd.2024.07.032

Textile based medical devices and their role in sustainable health systems (2024)
Thesis
Morris, H. V. Textile based medical devices and their role in sustainable health systems. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/956321

The field of medical textiles is one of the fastest growing areas within the technical textiles sector of the textile industry. Part of this expansion is because of advances in technology, such as nanotechnology, electrospinning, and the ability to i... Read More about Textile based medical devices and their role in sustainable health systems.

ColMA ‐based bioprinted 3D scaffold allowed to study tenogenic events in human tendon stem cells (2024)
Journal Article
Cortella, G., Lamparelli, E. P., Ciardulli, M. C., Lovecchio, J., Giordano, E., Maffulli, N., & Della Porta, G. (in press). ColMA ‐based bioprinted 3D scaffold allowed to study tenogenic events in human tendon stem cells. Bioengineering and Translational Medicine, 1-15. https://doi.org/10.1002/btm2.10723

The advent of bioprinting has enabled the creation of precise three‐dimensional (3D) cell cultures suitable for biomimetic in vitro models. In this study, we developed a novel protocol for 3D printing methacrylated collagen (ColMa, or PhotoCol®) comb... Read More about ColMA ‐based bioprinted 3D scaffold allowed to study tenogenic events in human tendon stem cells.

Antidepressants for pain management in adults with chronic pain: a network meta-analysis (2024)
Journal Article
Birkinshaw, H., Friedrich, C., Cole, P., Eccleston, C., Serfaty, M., Stewart, G., …Pincus, T. (2024). Antidepressants for pain management in adults with chronic pain: a network meta-analysis. Health Technology Assessment, 28(62), 1-155. https://doi.org/10.3310/mkrt2948

Background
Chronic pain is common and costly. Antidepressants are prescribed to reduce pain. However, there has not been a network meta-analysis examining all antidepressants across all chronic pain conditions, so effectiveness and safety for most a... Read More about Antidepressants for pain management in adults with chronic pain: a network meta-analysis.

Inhibition of matrix metalloproteinases to reduce blood brain barrier disruption and haemorrhagic transformation in ischaemic stroke: Go broad or go narrow? (2024)
Journal Article
Kawa, H., Ahmed, Z., Majid, A., & Chen, R. (in press). Inhibition of matrix metalloproteinases to reduce blood brain barrier disruption and haemorrhagic transformation in ischaemic stroke: Go broad or go narrow?. Neuropharmacology, 262, Article 110192. https://doi.org/10.1016/j.neuropharm.2024.110192

Ischaemic stroke characterises impulsive cerebral-region hypoxia due to deep intracerebral arteriole blockage, often accompanied by permanent cerebral infarction and cognitive impairment. Thrombolysis with recombinant tissue plasminogen activator (rt... Read More about Inhibition of matrix metalloproteinases to reduce blood brain barrier disruption and haemorrhagic transformation in ischaemic stroke: Go broad or go narrow?.

Loss of Consciousness in Judo: Not Always a Concussion (2024)
Journal Article
Singh, K., Malliaropoulos, N., Callan, M., Ikumi, A., & Maffulli, N. (in press). Loss of Consciousness in Judo: Not Always a Concussion. Clinical Journal of Sport Medicine, 1-2. https://doi.org/10.1097/jsm.0000000000001281

INTRODUCTION
All sports carry injury risks. In the event of loss of consciousness (LOC) in judo, and with an appropriate mechanism of injury, concussion is likely to be high on a list of potential causes. The diagnosis and management of concussion h... Read More about Loss of Consciousness in Judo: Not Always a Concussion.

Highest oxygen consumption prediction: introducing variable theoretical proportional factors for different sports (2024)
Journal Article
Lorenzo-Capellá, I., Ramos-Álvarez, J. J., Jiménez-Herranz, M. E., Maffulli, N., de Borba, E. F., Iuliano, E., …Padulo, J. (in press). Highest oxygen consumption prediction: introducing variable theoretical proportional factors for different sports. European Journal of Applied Physiology, https://doi.org/10.1007/s00421-024-05625-w

Purpose
The use of a fixed theoretical-proportional-factor (TPF15) is one of the indirect highest-oxygen-consumptions (HOC) assessment methods, but it may not accurately reflect the physiological differences across various sports (cycling-triathlon-... Read More about Highest oxygen consumption prediction: introducing variable theoretical proportional factors for different sports.

Pediatric wrist fractures: variations in management across countries. An evidence-based summary of evidence (2024)
Journal Article
Labianca, L., Calderaro, C., & Maffulli, N. (in press). Pediatric wrist fractures: variations in management across countries. An evidence-based summary of evidence. British Medical Bulletin, https://doi.org/10.1093/bmb/ldae014

Introduction
Fractures of the distal radius are common in pediatric population, with considerable variation in the management of pediatric wrist fractures across different countries. It is crucial to consider the different approaches to conservative... Read More about Pediatric wrist fractures: variations in management across countries. An evidence-based summary of evidence.