Outputs (2248)

Simulation and characterization of the corneal limbal epithelial stem cell niche by using new biotechnologies (2025)
Thesis
Dimmock, R. L. Simulation and characterization of the corneal limbal epithelial stem cell niche by using new biotechnologies. (Thesis). Keele University. https://keele-repository.worktribe.com/output/1109999

The limbal epithelial stem cell (LESC) niche is a vital stem cell pool which serves to replenish the cornea with competent stem cells for regrowth and repair throughout adult life. Injury and disease, such as limbal stem cell deficiency (LSCD), can d... Read More about Simulation and characterization of the corneal limbal epithelial stem cell niche by using new biotechnologies.

Application of musculoskeletal modelling to evaluate movement and muscle activity patterns in shoulder instability (2025)
Thesis
Seyres, M. A. Application of musculoskeletal modelling to evaluate movement and muscle activity patterns in shoulder instability. (Thesis). Keele University. https://keele-repository.worktribe.com/output/1109341

Shoulder instability is a complex impairment that presents as the shoulder sliding out of its support. It challenges current clinical practice in its definition, assessment, classification and long-term outcome. An improved understanding of its mecha... Read More about Application of musculoskeletal modelling to evaluate movement and muscle activity patterns in shoulder instability.

A comprehensive proteomic and bioinformatics analysis of human spinal cord injury plasma identifies proteins associated with the complement cascade and liver function as potential prognostic indicators of neurological outcome (2025)
Journal Article
Harrington, G. M. B., Cool, P., Hulme, C., Stokes-Fisher, J., Peffers, M., El Masri, W., Osman, A., Chowdhury, J. R., Kumar, N., Budithi, S., & Wright, K. (2025). A comprehensive proteomic and bioinformatics analysis of human spinal cord injury plasma identifies proteins associated with the complement cascade and liver function as potential prognostic indicators of neurological outcome. Journal of Neurotrauma, 42(3-4), https://doi.org/10.1101/2022.07.12.499696

Spinal cord injury (SCI) is a major cause of disability, with complications postinjury often leading to lifelong health issues with the need for extensive treatment. Neurological outcome post-SCI can be variable and difficult to predict, particularly... Read More about A comprehensive proteomic and bioinformatics analysis of human spinal cord injury plasma identifies proteins associated with the complement cascade and liver function as potential prognostic indicators of neurological outcome.

Development, characterisation and application of a novel nanofiber-based 3D technique for isolation, enrichment and purification of extracellular vesicles from mesenchymal stem cells (2024)
Thesis
Alfred, K. I. Development, characterisation and application of a novel nanofiber-based 3D technique for isolation, enrichment and purification of extracellular vesicles from mesenchymal stem cells. (Thesis). Keele University. https://keele-repository.worktribe.com/output/1015802

Extracellular vesicles (EVs) are nanoscale, lipid-bound particles carrying bioactive molecules produced by cells. Mesenchymal stem cells (MSC) are preferred sources for producing therapeutically relevant EVs (MSC-EVs). Nonetheless, harnessing MSC-EVs... Read More about Development, characterisation and application of a novel nanofiber-based 3D technique for isolation, enrichment and purification of extracellular vesicles from mesenchymal stem cells.

Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model (2024)
Journal Article
Perry, J., Mennan, C., Cool, P., McCarthy, H., Newell, K., Hopkins, T., Hulme, C., Wright, K., Henson, F., & Roberts, S. (2024). Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model. Cartilage, https://doi.org/10.1177/19476035241287832

Objective
To determine if mesenchymal stromal cells (MSCs) derived from human umbilical cords (hUC) could reduce degeneration developing when injected into the knee of a large animal model of osteoarthritis (OA).
Design
Ten million culture-expande... Read More about Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model.

125P A review of the management and outcomes of children with SMA in the West Midlands, UK during 2017-2022 (2024)
Presentation / Conference Contribution
Willis, T., Kulshrestha, R., Alhaswani, Z., Parasuraman, D., Kuiper, J., Jones, J., & Perry, C. 125P A review of the management and outcomes of children with SMA in the West Midlands, UK during 2017-2022. Presented at 29th World Muscle Society Congress, Prague, Czechia

Textile based medical devices and their role in sustainable health systems (2024)
Thesis
Morris, H. V. Textile based medical devices and their role in sustainable health systems. (Thesis). Keele University. https://keele-repository.worktribe.com/output/956321

The field of medical textiles is one of the fastest growing areas within the technical textiles sector of the textile industry. Part of this expansion is because of advances in technology, such as nanotechnology, electrospinning, and the ability to i... Read More about Textile based medical devices and their role in sustainable health systems.

ColMA ‐based bioprinted 3D scaffold allowed to study tenogenic events in human tendon stem cells (2024)
Journal Article
Cortella, G., Lamparelli, E. P., Ciardulli, M. C., Lovecchio, J., Giordano, E., Maffulli, N., & Della Porta, G. (in press). ColMA ‐based bioprinted 3D scaffold allowed to study tenogenic events in human tendon stem cells. Bioengineering and Translational Medicine, 1-15. https://doi.org/10.1002/btm2.10723

The advent of bioprinting has enabled the creation of precise three‐dimensional (3D) cell cultures suitable for biomimetic in vitro models. In this study, we developed a novel protocol for 3D printing methacrylated collagen (ColMa, or PhotoCol®) comb... Read More about ColMA ‐based bioprinted 3D scaffold allowed to study tenogenic events in human tendon stem cells.

Antidepressants for pain management in adults with chronic pain: a network meta-analysis (2024)
Journal Article
Birkinshaw, H., Friedrich, C., Cole, P., Eccleston, C., Serfaty, M., Stewart, G., White, S., Moore, A., Phillippo, D., & Pincus, T. (2024). Antidepressants for pain management in adults with chronic pain: a network meta-analysis. Health Technology Assessment, 28(62), 1-155. https://doi.org/10.3310/mkrt2948

Background
Chronic pain is common and costly. Antidepressants are prescribed to reduce pain. However, there has not been a network meta-analysis examining all antidepressants across all chronic pain conditions, so effectiveness and safety for most a... Read More about Antidepressants for pain management in adults with chronic pain: a network meta-analysis.

Inhibition of matrix metalloproteinases to reduce blood brain barrier disruption and haemorrhagic transformation in ischaemic stroke: Go broad or go narrow? (2024)
Journal Article
Kawa, H., Ahmed, Z., Majid, A., & Chen, R. (in press). Inhibition of matrix metalloproteinases to reduce blood brain barrier disruption and haemorrhagic transformation in ischaemic stroke: Go broad or go narrow?. Neuropharmacology, 262, Article 110192. https://doi.org/10.1016/j.neuropharm.2024.110192

Ischaemic stroke characterises impulsive cerebral-region hypoxia due to deep intracerebral arteriole blockage, often accompanied by permanent cerebral infarction and cognitive impairment. Thrombolysis with recombinant tissue plasminogen activator (rt... Read More about Inhibition of matrix metalloproteinases to reduce blood brain barrier disruption and haemorrhagic transformation in ischaemic stroke: Go broad or go narrow?.