An investigation into the role of dendrimers as potential enhancers of the dermal delivery of topically applied chlorhexidine

Abstract

The reduction of bacteria on the skin results in prophylactic and therapeutic benefits by reducing the occurrence of skin infections. Currently, chlorhexidine digluconate, a conventional topical antiseptic, permeates the skin poorly leaving viable opportunistic pathogens below the superficial layers of the stratum corneum. The aim of this study was to use polyamidoamine (PAMAM) dendrimers to enhance the topical delivery of chlorhexidine digluconate to improve its antimicrobial efficacy.

Citation

(2013). An investigation into the role of dendrimers as potential enhancers of the dermal delivery of topically applied chlorhexidine

• Keywords: bacteria skin infections polyamidoamine dendrimers PAMAM chlorhexidine digluconate