Gout and risk of chronic kidney disease and nephrolithiasis: meta-analysis of observational studies

Mallen; Roddy; Belcher

Abstract

ntroduction
To determine the prevalence of chronic kidney disease and nephrolithiasis in people with gout, and the association between gout and prevalent or incident chronic kidney disease and nephrolithiasis.

Methods
Systematic review and meta-analysis of epidemiological studies. Data sources; MEDLINE, EMBASE and CINAHL databases, hand-searched reference lists, citation history and contact with authors. Eligibility criteria: cohort, case–control or cross-sectional studies which examined the occurrence of chronic kidney disease or nephrolithiasis amongst adults with gout (with or without a non-gout comparator group) in primary care or general population samples. Prevalence and risk estimate meta-analyses were performed using a random-effects model.

Results
Seventeen studies were included in the meta-analysis (chronic kidney disease n?=?7, nephrolithiasis n?=?8, both n?=?2). Pooled prevalence estimates of chronic kidney disease stage =3 and self-reported lifetime nephrolithiasis in people with gout were 24% (95% confidence interval 19% to 28%) and 14% (95% CI 12% to 17%) respectively. Gout was associated with both chronic kidney disease (pooled adjusted odds ratio 2.41, 95% confidence interval 1.86 to 3.11) and self-reported lifetime nephrolithiasis (1.77, 1.43 to 2.19).

Conclusions
Chronic kidney disease and nephrolithiasis are commonly found amongst patients with gout. Gout is independently associated with both chronic kidney disease and nephrolithiasis. Patients with gout should be actively screened for chronic kidney disease and its consequences.

Citation

Mallen, Roddy, & Belcher. (2015). Gout and risk of chronic kidney disease and nephrolithiasis: meta-analysis of observational studies. Arthritis Research and Therapy, 17, Article 90. https://doi.org/10.1186/s13075-015-0610-9

• Acceptance Date: Mar 24, 2015
• Publication Date: Apr 1, 2015
• Publicly Available Date: May 26, 2023
• Journal: Arthritis Research and Therapy
• Print ISSN: 1478-6354
• Electronic ISSN: 1478-6362
• Publisher: Springer Verlag
• Peer Reviewed: Peer Reviewed
• Volume: 17
• Article Number: 90
• DOI: https://doi.org/10.1186/s13075-015-0610-9
• Keywords: gout, kidney disease
• Public URL: https://keele-repository.worktribe.com/output/403854
• Publisher URL: https://doi.org/10.1186/s13075-015-0610-9