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Determination of formulation factors that affect oral medicines acceptability in a domicilliary paediatric population

Venables

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Authors

Venables



Abstract

Acceptability of medicines for children is a challenge, yet critical to ensure adherence to treatment. There is very little literature on formulation factors that influence acceptability of medicines, particularly in the domiciliary environment. This pragmatic study was conducted at University Hospital Coventry and Warwickshire (UHCW) with the aim of identifying the prevalence and nature of oral formulation-related barriers to medicines administration in children suffering from long-term conditions.

This study used semi-structured face-to-face interviews with 221 parents/carers of children (0–18 years) and 57 young people (12–18 years).

Result
showed significant medicines refusal and manipulation in the domiciliary environment. Nearly one-third (71/232) of respondents reported medicines refusal. This was associated significantly with the age of child (p = 0.016), socioeconomic status (IMD 2010 score) (p = 0.002), taste (p < 0.001), texture (p = 0.017), and volume (of liquid/powder) or quantity (of solid dosage form) (p < 0.001). 29% (74/252) of respondents reported manipulating medicines. P-values are based on multivariable statistical analysis models.

This study has indicated that formulations prescribed to children with chronic conditions are not meeting the needs of a significant number of patients based on self-report. Age-appropriate medicines are required to provide suitable dose units with an acceptable taste for children. This study should aid pharmaceutical companies to prioritise paediatric formulation work.

Citation

Venables. (2015). Determination of formulation factors that affect oral medicines acceptability in a domicilliary paediatric population. International Journal of Pharmaceutics, 55 - 62. https://doi.org/10.1016/j.ijpharm.2015.01.023

Acceptance Date Jan 13, 2015
Publication Date Jan 16, 2015
Journal International Journal of Pharmaceutics
Print ISSN 0378-5173
Publisher Elsevier
Pages 55 - 62
DOI https://doi.org/10.1016/j.ijpharm.2015.01.023
Keywords Pediatric, Medicines, Formulation, Acceptability, Organoleptic
Publisher URL https://doi.org/10.1016/j.ijpharm.2015.01.023

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