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The influence of hydrostatic pressure on tissue engineered bone development

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Abstract

The hydrostatic pressure stimulation of an appropriately cell–seeded porous scaffold within a bioreactor is a promising method for engineering bone tissue external to the body. We propose a mathematical model, and employ a suite of candidate constitutive laws, to qualitatively describe the effect of applied hydrostatic pressure on the quantity of minerals deposited in such an experimental setup. By comparing data from numerical simulations with experimental observations under a number of stimulation protocols, we suggest that the response of bone cells to an applied pressure requires consideration of two components; i) a component describing the cell memory of the applied stimulation, and ii) a recovery component, capturing the time cells require to recover from high rates of mineralisation.

Citation

(2016). The influence of hydrostatic pressure on tissue engineered bone development. Journal of Theoretical Biology, https://doi.org/10.1016/j.jtbi.2015.12.020

Acceptance Date Dec 17, 2015
Publication Date Jan 18, 2016
Journal Journal of Theoretical Biology
Print ISSN 0022-5193
Publisher Elsevier
DOI https://doi.org/10.1016/j.jtbi.2015.12.020
Keywords modelling, tissue engineering, ordinary differential equation, biomechanical response
Publisher URL http://www.sciencedirect.com/science/article/pii/S0022519316000254

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