Stanislaw Glazewski
Time-course and mechanisms of homeostatic plasticity in layers 2/3 and 5 of the barrel cortex
Glazewski, Stanislaw; Greenhill, Stuart; Fox, Kevin
Authors
Stuart Greenhill
Kevin Fox
Abstract
Recent studies have shown that ocular dominance plasticity in layer 2/3 of the visual cortex exhibits a form of homeostatic plasticity that is related to synaptic scaling and depends on TNFa. In this study, we tested whether a similar form of plasticity was present in layer 2/3 of the barrel cortex and, therefore, whether the mechanism was likely to be a general property of cortical neurons. We found that whisker deprivation could induce homeostatic plasticity in layer 2/3 of barrel cortex, but not in a mouse strain lacking synaptic scaling. The time-course of homeostatic plasticity in layer 2/3 was similar to that of L5 regular spiking (RS) neurons (L5RS), but slower than that of L5 intrinsic bursting (IB) neurons (L5IB). In layer 5, the strength of evoked whisker responses and ex vivo miniature excitatory post-synaptic currents (mEPSCs) amplitudes showed an identical time-course for homeostatic plasticity, implying that plasticity at excitatory synapses contacting layer 5 neurons is sufficient to explain the changes in evoked responses. Spontaneous firing rate also showed homeostatic behaviour for L5IB cells, but was absent for L5RS cells over the time-course studied. Spontaneous firing rate homeostasis was found to be independent of evoked response homeostasis suggesting that the two depend on different mechanisms.
Citation
Glazewski, S., Greenhill, S., & Fox, K. (2017). Time-course and mechanisms of homeostatic plasticity in layers 2/3 and 5 of the barrel cortex. Philosophical Transactions B: Biological Sciences, 372(1715), https://doi.org/10.1098/rstb.2016.0150
Journal Article Type | Article |
---|---|
Acceptance Date | Oct 4, 2016 |
Publication Date | Jan 16, 2017 |
Journal | Philosophical Transactions B: Biological Sciences |
Print ISSN | 0962-8436 |
Publisher | The Royal Society |
Peer Reviewed | Peer Reviewed |
Volume | 372 |
Issue | 1715 |
DOI | https://doi.org/10.1098/rstb.2016.0150 |
Keywords | synapse, LTP, experience-dependent, LTD, Q2 synaptic scaling, sensory cortex |
Publisher URL | http://dx.doi.org/10.1098/rstb.2016.0150 |
Files
RSTB20160150p.pdf.pdf
(723 Kb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by-nc/4.0/
You might also like
Astrocyte and Neuronal Plasticity in the Somatosensory System
(2015)
Journal Article
Downloadable Citations
About Keele Repository
Administrator e-mail: research.openaccess@keele.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search