Effects of glutathione S-transferase M1, T1 and P1 on lung function in asthmatic families.

Carroll, W.D.; Lenney, W.; Jones, P.W.; Strange, R.C.; Child, F.; Whyte, M.K.; Primhak, R.A.; Fryer, A.A.

Abstract

RATIONALE: Previous data have suggested that glutathione-S-transferase (GST) genotypes are important in determining the rate of lung function growth in childhood. This effect was most marked in Caucasian children with asthma. OBJECTIVES: We investigated the association of lung function with GSTM1, GSTP1 and GSTT1 genotypes in Caucasian families with asthma. METHODS: Four hundred and eighteen children and 316 parents from 224 Caucasian families were recruited via a child with asthma, the proband. Associations between lung function and GST genotype were determined using multilevel models. RESULTS: There were no observed associations between lung function and GST genotype in parents. However, in the children, the GSTP1 val(105)/val(105) and GSTM1 null genotypes were associated with significantly higher forced expiratory volume in 1 s (FEV(1)) and FVC values as percentage of predicted. This effect was not statistically significant in the probands but was marked in their siblings in whom GSTP1 val(105)/val(105) was associated with 9.4% higher FEV(1) and 10.7% higher FVC (P=0.005 and 0.001, respectively). The GSTM1 null genotype was associated with a 6.7% higher FEV(1) and 4.1% higher FVC (P=0.003 and 0.063, respectively). These effects remained significant after correcting for the confounders of individual atopic status, tobacco smoke exposure and familial aggregation of lung function values. CONCLUSIONS: GSTM1 and GSTP1 genotypes are important determinants of lung function in childhood. The smaller differences seen in probands are predicted by a simple model in which more rapid decline in lung function is seen in these individuals.

Citation

Carroll, W., Lenney, W., Jones, P., Strange, R., Child, F., Whyte, M., Primhak, R., & Fryer, A. (2005). Effects of glutathione S-transferase M1, T1 and P1 on lung function in asthmatic families. Clinical and Experimental Allergy, 35(9), 1155 - 1161. https://doi.org/10.1111/j.1365-2222.2005.02313.x

• Journal Article Type: Article
• Acceptance Date: Sep 14, 2005
• Online Publication Date: Sep 14, 2005
• Publication Date: 2005-09
• Journal: Clinical and Experimental Allergy
• Print ISSN: 0954-7894
• Electronic ISSN: 1365-2222
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 35
• Issue: 9
• Pages: 1155 - 1161
• DOI: https://doi.org/10.1111/j.1365-2222.2005.02313.x
• Public URL: https://keele-repository.worktribe.com/output/408590
• Publisher URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2222.2005.02313.x/abstract
• PMID: 16164441