Harnessing open-source technology for low-cost automation in synthesis: flow chemical deprotection of silyl ethers using a homemade autosampling system.

O'Brien, M; Konings, L; Martin, M; Heap, J

Abstract

An inexpensive homemade 3-axis autosampler was used to facilitate the automation of an acid catalysed flow chemical desilylation reaction. Harnessing open-source software technologies (Python, OpenCV), an automated computer-vision controlled liquid-liquid extraction step was used to provide effective inline purification. A Raspberry Pi single-board computer was employed to interface with the motors used in the autosampler and actuated fluidic valves.

Citation

O'Brien, M., Konings, L., Martin, M., & Heap, J. (2017). Harnessing open-source technology for low-cost automation in synthesis: flow chemical deprotection of silyl ethers using a homemade autosampling system. Tetrahedron Letters, 2409-2413. https://doi.org/10.1016/j.tetlet.2017.05.008

• Acceptance Date: May 3, 2017
• Publication Date: May 5, 2017
• Journal: Tetrahedron Letters
• Print ISSN: 0040-4039
• Publisher: Elsevier
• Pages: 2409-2413
• DOI: https://doi.org/10.1016/j.tetlet.2017.05.008
• Keywords: open-source, automation, flow chemistry, desilylation, liquid-liquid extraction
• Publisher URL: https://doi.org/10.1016/j.tetlet.2017.05.008