Skip to main content

Research Repository

Advanced Search

Chemical Synthesis of S-linked Glycosaminoglycans (2025)
Thesis
O’Shea, C. (2025). Chemical Synthesis of S-linked Glycosaminoglycans. (Thesis). Keele University. https://keele-repository.worktribe.com/output/1280018

Heparan sulfate (HS), a sulfated linear carbohydrate that decorates the cell surface and extracellular matrix, is ubiquitously distributed throughout the animal kingdom and represents a key regulator of biological processes. An example of a glycosami... Read More about Chemical Synthesis of S-linked Glycosaminoglycans.

Chemical synthesis of glycosaminoglycan mimetics for targeting endoglycosidase activity (2025)
Thesis
Wootton, H. S. (2025). Chemical synthesis of glycosaminoglycan mimetics for targeting endoglycosidase activity. (Thesis). Keele University. https://keele-repository.worktribe.com/output/1279726

Glycosaminoglycans are a family of extraordinary, long-chain polysaccharides that are highly abundant on the mammalian cell surface and in the extracellular matrix. These linear chains exist as proteoglycans which perform critical roles in many biolo... Read More about Chemical synthesis of glycosaminoglycan mimetics for targeting endoglycosidase activity.

Understanding chromotropic materials with combined insitu Neutron Diffraction and Raman Spectroscopy (2024)
Thesis
Dugmore, S. K. Understanding chromotropic materials with combined insitu Neutron Diffraction and Raman Spectroscopy. (Thesis). Keele University. https://keele-repository.worktribe.com/output/1012545

In recent years, in many fields of scientific research, the multi-technique approach has grown into a robust method for the experimental characterisation of complex materials. The combination of diffraction, spectroscopy and other non-destructive tec... Read More about Understanding chromotropic materials with combined insitu Neutron Diffraction and Raman Spectroscopy.

Synthesis of S-Glycoside Building Blocks as Mimetics of the Repeating d-GlcN-α-1,4-d-GlcA Heparan Sulfate Disaccharide (2024)
Journal Article
O’Shea, C., & Miller, G. J. (2024). Synthesis of S-Glycoside Building Blocks as Mimetics of the Repeating d-GlcN-α-1,4-d-GlcA Heparan Sulfate Disaccharide. Molecules, 29(23), Article 5809. https://doi.org/10.3390/molecules29235809

Heparan sulfate (HS), a sulfated linear carbohydrate that decorates the cell surface and extracellular matrix, is a key regulator of biological processes. Owing to the inherent structural complexity of HS, structure-to-function studies with its ligan... Read More about Synthesis of S-Glycoside Building Blocks as Mimetics of the Repeating d-GlcN-α-1,4-d-GlcA Heparan Sulfate Disaccharide.

Structural and ion exchange study of nanostructured materials (2024)
Thesis
Contini, A. Structural and ion exchange study of nanostructured materials. (Thesis). Keele University. https://keele-repository.worktribe.com/output/857282

In this thesis, the structural and acidic properties of two zeolites LTL and MAZ are compared and reported. Commercial LTL and MAZ were ion exchanged with metal alkali cations, to obtain the corresponding ion exchanged forms, and characterised by IR... Read More about Structural and ion exchange study of nanostructured materials.

Chemical synthesis approaches to amphiphilic mimetic glycosides (2024)
Thesis
Porter, J. A. Chemical synthesis approaches to amphiphilic mimetic glycosides. (Thesis). Keele University. https://keele-repository.worktribe.com/output/849924

The majority of surfactants in use are derived from petroleum feedstocks. Synthetic surfactants face numerous issues including low biodegradability, ecotoxicity and bioaccumulation. Biosurfactants such as amphiphilic glycoconjugates are a promising c... Read More about Chemical synthesis approaches to amphiphilic mimetic glycosides.

Evaluation of chemometric software for analysis of complex mixtures for biologically derived samples analysed using liquid-chromatography mass spectrometry (2024)
Thesis
Scott, M. R. Evaluation of chemometric software for analysis of complex mixtures for biologically derived samples analysed using liquid-chromatography mass spectrometry. (Thesis). Keele University. https://keele-repository.worktribe.com/output/850250

There is a risk of losing important information when choosing the best metabolomic workflow for untargeted chemometric analysis. Choosing the best software for conducting this analysis is crucial as wrong parameters with the wrong software could lead... Read More about Evaluation of chemometric software for analysis of complex mixtures for biologically derived samples analysed using liquid-chromatography mass spectrometry.

Bioprocess development for aliphatic alcohol oxidation and alkyl glycoside purification using biocatalysis (2024)
Thesis
Wahart, A. J. C. Bioprocess development for aliphatic alcohol oxidation and alkyl glycoside purification using biocatalysis. (Thesis). Keele University. https://keele-repository.worktribe.com/output/853204

The detergents and skin care products are composed of surfactants that decrease interfacial tension between two phases (i.e. oil and water).1 Before the ecological dangers issued from nonrenewable sources surfactants (pollution of aqueous environment... Read More about Bioprocess development for aliphatic alcohol oxidation and alkyl glycoside purification using biocatalysis.

Comprehensive utilisation of hydrogen gas for the efficient use of proton exchange membrane fuel cell powered vehicles (2024)
Thesis
Latham-Wheawall, L. Comprehensive utilisation of hydrogen gas for the efficient use of proton exchange membrane fuel cell powered vehicles. (Thesis). Keele University. https://keele-repository.worktribe.com/output/775441

The need for clean energy is not being met and is increasing each day. One immensely underused technology – proton exchange membrane fuel cells, can drastically help to deliver green energy and prevent the worsening of climate change. However, in ord... Read More about Comprehensive utilisation of hydrogen gas for the efficient use of proton exchange membrane fuel cell powered vehicles.

Exploring the full range of N⋯I⋯X halogen-bonding interactions within a single compound using pressure † (2024)
Journal Article
Jones, R. H., Bull, C. L., Funnell, N. P., Knight, K. S., & Marshall, W. G. (in press). Exploring the full range of N⋯I⋯X halogen-bonding interactions within a single compound using pressure †. Chemical Communications, https://doi.org/10.1039/D4CC00847B

The response of the trimethylammonium–iodinechloride and diiodide (TMA–ICl/I2) crystal structures have been examined under high pressure using neutron powder diffraction. TMA–ICl exhibits impressive pressure-driven electronic flexibility, where the N... Read More about Exploring the full range of N⋯I⋯X halogen-bonding interactions within a single compound using pressure †.

Sustainable supercapacitor with a natural rubber-based electrolyte and natural graphite-based electrodes (2023)
Journal Article
Perera, K., Vidanapathirana, K., Adams, L. J., & Balakrishnan, N. (2023). Sustainable supercapacitor with a natural rubber-based electrolyte and natural graphite-based electrodes. Electrochemical Science Advances, Article e2300025. https://doi.org/10.1002/elsa.202300025

Supercapacitors are at the forefront of energy storage devices due to their ability to fulfill quick power requirements. However, safety and cost are important parameters for their real-world applications. Green materials-based electrodes and electro... Read More about Sustainable supercapacitor with a natural rubber-based electrolyte and natural graphite-based electrodes.

Juggling Optoelectronics and Catalysis: The Dual Talents of Bench Stable 1,4‐Azaborinines (2023)
Journal Article
van Beek, C. M., Swarbrook, A. M., Creissen, C. E., Hawes, C. S., Gazis, T. A., & Matthews, P. D. (2023). Juggling Optoelectronics and Catalysis: The Dual Talents of Bench Stable 1,4‐Azaborinines. Chemistry - A European Journal, 30(8), Article e202301944. https://doi.org/10.1002/chem.202301944

Boron‐ and nitrogen‐doped polycyclic aromatic hydrocarbons (B‐PAHs) have established a strong foothold in the realm of organic electronics. However, their catalytic potential remains largely untapped. In this study, we synthesise and characterise two... Read More about Juggling Optoelectronics and Catalysis: The Dual Talents of Bench Stable 1,4‐Azaborinines.

Magnesium oxide loaded mesoporous silica: Synthesis, characterisation and use in removing lead and cadmium from water supplies (2023)
Journal Article
Saod, W., Oliver, I., Thompson, D., Holborn, S., Contini, A., Zholobenko, V., & Zholobenko, V. (2023). Magnesium oxide loaded mesoporous silica: Synthesis, characterisation and use in removing lead and cadmium from water supplies. Environmental Nanotechnology, Monitoring & Management, https://doi.org/10.1016/j.enmm.2023.100817

Water pollution by potentially toxic elements such as cadmium (Cd) and lead (Pb) is a persistent problem in many parts of the world. It continues to have profound implications for drinking water supplies, wastewater discharge and environmental qualit... Read More about Magnesium oxide loaded mesoporous silica: Synthesis, characterisation and use in removing lead and cadmium from water supplies.

Using the solid injection technique with gas chromatography and mass spectrometry to identify cuticular hydrocarbons in several thrips insect species (2023)
Thesis
Covaci, A.-D. Using the solid injection technique with gas chromatography and mass spectrometry to identify cuticular hydrocarbons in several thrips insect species. (Thesis). Keele University. https://keele-repository.worktribe.com/output/597582

Thrips are a group of insects included in the order Thysanoptera. So far, over 6000 species have been described, among which over 100 are known as crop pests There is a plethora of studies on various species of thrips, yet the CHC composition is know... Read More about Using the solid injection technique with gas chromatography and mass spectrometry to identify cuticular hydrocarbons in several thrips insect species.

Supramolecular Polymer Polymorphism: Spontaneous Helix-Helicoid Transition through Dislocation of Hydrogen-Bonded π-Rosettes. (2023)
Journal Article
Otsuka, C., Takahashi, S., Isobe, A., Saito, T., Aizawa, T., Tsuchida, R., Yamashita, S., Harano, K., Hanayama, H., Shimizu, N., Takagi, H., Haruki, R., Liu, L., Hollamby, M. J., Ohkubo, T., Yagai, S., & Hollamby, M. J. (2023). Supramolecular Polymer Polymorphism: Spontaneous Helix-Helicoid Transition through Dislocation of Hydrogen-Bonded π-Rosettes. Journal of the American Chemical Society, 145(41), 22563-22576. https://doi.org/10.1021/jacs.3c07556

Polymorphism, a phenomenon whereby disparate self-assembled products can be formed from identical molecules, has incited interest in the field of supramolecular polymers. Conventionally, the monomers that constitute supramolecular polymers are engine... Read More about Supramolecular Polymer Polymorphism: Spontaneous Helix-Helicoid Transition through Dislocation of Hydrogen-Bonded π-Rosettes..

Indolo[2,3- e ]benzazocines and indolo[2,3- f ]benzazonines and their copper( ii ) complexes as microtubule destabilizing agents † (2023)
Journal Article
Wittmann, C., Dömötör, O., Kuznetcova, I., Spengler, G., Reynisson, J., Holder, L., Miller, G. J., Enyedy, E. A., Bai, R., Hamel, E., & Arion, V. B. (2023). Indolo[2,3- e ]benzazocines and indolo[2,3- f ]benzazonines and their copper( ii ) complexes as microtubule destabilizing agents †. Dalton Transactions, 52(29), 9964-9982. https://doi.org/10.1039/d3dt01632c

A series of four indolo[2,3-e]benzazocines HL1–HL4 and two indolo[2,3-f]benzazonines HL5 and HL6, as well as their respective copper(ii) complexes 1–6, were synthesized and characterized by 1H and 13C NMR spectroscopy, ESI mass spectrometry, single c... Read More about Indolo[2,3- e ]benzazocines and indolo[2,3- f ]benzazonines and their copper( ii ) complexes as microtubule destabilizing agents †.

Chemical synthesis of fluorinated carbocyclic nucleoside analogues (2023)
Thesis
Benckendorff, C. M. M. Chemical synthesis of fluorinated carbocyclic nucleoside analogues. (Thesis). Keele University. https://keele-repository.worktribe.com/output/529473

Since the discovery of their pharmaceutical potential, nucleoside analogues have become one of the most important classes of chemotherapeutic agents in the treatment of many cancers and viral infections. In many chronic illnesses, such as HBV or HIV... Read More about Chemical synthesis of fluorinated carbocyclic nucleoside analogues.

ATR-FTIR spectroscopy of heparin: using multivariate analyses for next-generation quality control (2023)
Thesis
Devlin, A. J. ATR-FTIR spectroscopy of heparin: using multivariate analyses for next-generation quality control. (Thesis). Keele University. https://keele-repository.worktribe.com/output/518613

Heparin is a member of the glycosaminoglycan (GAG) family of naturally occurring, polydisperse, linear polysaccharides. Heparin is a ubiquitous anticoagulant drug, a member of the WHO’s list of vital medicines and the second used drug by weight after... Read More about ATR-FTIR spectroscopy of heparin: using multivariate analyses for next-generation quality control.

The evaluation of a metabonomic approach to detect decomposition products in water and leachates using Liquid Chromatography-Mass Spectrometry (2023)
Thesis
Williams, M. F. The evaluation of a metabonomic approach to detect decomposition products in water and leachates using Liquid Chromatography-Mass Spectrometry. (Thesis). Keele University. https://keele-repository.worktribe.com/output/515544

Statistics show that there was a 12% increase in missing persons’ incidents in the UK between 2014 and 2019. Approximately 50% of these missing individuals are found within 24 hours, and on average a large number will be deceased. Land-based searches... Read More about The evaluation of a metabonomic approach to detect decomposition products in water and leachates using Liquid Chromatography-Mass Spectrometry.