Continuous flow iodination using an automated computer-vision controlled liquid-liquid extraction system

O'Brien, M; Cooper, DA; Dolan, Jonathan

Abstract

Abstract A dynamic computer-vision control system incorporating open-source software technologies (Python, OpenCV) was used to automate a gravity based in-line liquid-liquid extraction during the iodination of enaminones in continuous flow. The system was able to cope with significant colouration of the organic reaction stream and with significant volume/flow changes in the aqueous and organic phase streams due to extraction of the water soluble acetonitrile co-solvent.

Citation

O'Brien, M., Cooper, D., & Dolan, J. (2017). Continuous flow iodination using an automated computer-vision controlled liquid-liquid extraction system. Tetrahedron Letters, 829 - 834. https://doi.org/10.1016/j.tetlet.2017.01.029

• Journal Article Type: Article
• Acceptance Date: Jan 10, 2017
• Publication Date: Mar 1, 2017
• Journal: Tetrahedron Letters
• Print ISSN: 0040-4039
• Publisher: Elsevier
• Pages: 829 - 834
• DOI: https://doi.org/10.1016/j.tetlet.2017.01.029
• Keywords: open-source, automation, computer-vision, continuous-flow, iodination
• Publisher URL: http://www.sciencedirect.com/science/article/pii/S0040403917300515