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Causal evidence that intrinsic beta frequency is relevant for enhanced signal propagation in the motor system as shown through rhythmic TMS

Romei, Vincenzo; Bauer, Markus; Brooks, Joseph L.; Economides, Marcos; Penny, Will; Thut, Gregor; Driver, Jon; Bestmann, Sven

Causal evidence that intrinsic beta frequency is relevant for enhanced signal propagation in the motor system as shown through rhythmic TMS Thumbnail


Authors

Vincenzo Romei

Markus Bauer

Marcos Economides

Will Penny

Gregor Thut

Jon Driver

Sven Bestmann



Abstract

Correlative evidence provides support for the idea that brain oscillations underpin neural computations. Recent work using rhythmic stimulation techniques in humans provide causal evidence but the interactions of these external signals with intrinsic rhythmicity remain unclear. Here, we show that sensorimotor cortex follows externally applied rhythmic TMS (rTMS) stimulation in the beta-band but that the elicited responses are strongest at the intrinsic individual beta peak frequency. While these entrainment effects are of short duration, even subthreshold rTMS pulses propagate through the network and elicit significant cortico-spinal coupling, particularly when stimulated at the individual beta-frequency. Our results show that externally enforced rhythmicity interacts with intrinsic brain rhythms such that the individual peak frequency determines the effect of rTMS. The observed downstream spinal effect at the resonance frequency provides evidence for the causal role of brain rhythms for signal propagation.

Citation

Romei, V., Bauer, M., Brooks, J. L., Economides, M., Penny, W., Thut, G., …Bestmann, S. (2016). Causal evidence that intrinsic beta frequency is relevant for enhanced signal propagation in the motor system as shown through rhythmic TMS. NeuroImage, 126, 120 -130. https://doi.org/10.1016/j.neuroimage.2015.11.020

Journal Article Type Article
Acceptance Date Nov 9, 2015
Online Publication Date Nov 14, 2015
Publication Date Feb 1, 2016
Publicly Available Date May 26, 2023
Journal NeuroImage
Print ISSN 1053-8119
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 126
Pages 120 -130
DOI https://doi.org/10.1016/j.neuroimage.2015.11.020
Publisher URL http://doi.org/10.1016/j.neuroimage.2015.11.020

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