An open-source approach to automation in organic synthesis: The flow chemical formation of benzamides using an inline liquid-liquid extraction system and a homemade 3-axis autosampling/product-collection device

O'Brien, M; Hall, A; Schrauwen, J; van der Made, J

Abstract

Several open-source hardware and software technologies (RAMPS, Python, PySerial, OpenCV) were used to control an automated flow chemical synthesis system. The system was used to effect the synthesis of a series of benzamides. An inexpensive Raspberry Pi single board computer provided an electronic interface between the control computer and the RAMPS motor driver boards.

Citation

O'Brien, M., Hall, A., Schrauwen, J., & van der Made, J. (2018). An open-source approach to automation in organic synthesis: The flow chemical formation of benzamides using an inline liquid-liquid extraction system and a homemade 3-axis autosampling/product-collection device. Tetrahedron, 3152-3157. https://doi.org/10.1016/j.tet.2018.02.043

• Acceptance Date: Feb 19, 2018
• Publication Date: Feb 21, 2018
• Journal: Tetrahedron
• Print ISSN: 0040-4020
• Publisher: Elsevier
• Pages: 3152-3157
• DOI: https://doi.org/10.1016/j.tet.2018.02.043
• Keywords: Low-cost-automation; Open-source; Python; OpenCV; Raspberry-Pi; Flow-chemistry; Amide-formation; Liquid-liquid extraction
• Publisher URL: https://doi.org/10.1016/j.tet.2018.02.043