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Retroperitoneal Hemorrhage After Percutaneous Coronary Intervention: Incidence, Determinants, and Outcomes as Recorded by the British Cardiovascular Intervention Society.

Kontopantelis, E; Kinnaird, T; Potts, J; Rashid, M; Shoaib, A; Nolan, J; Bagur, R; de Belder, MA; Ludman, P; Kwok, CS; Mamas, M; Cardiovascular Intervention Society (BCIS) and National, British

Authors

E Kontopantelis

T Kinnaird

A Shoaib

R Bagur

MA de Belder

P Ludman

CS Kwok

British Cardiovascular Intervention Society (BCIS) and National



Abstract

BACKGROUND: Retroperitoneal hemorrhage (RH) is a rare bleeding complication of percutaneous coronary intervention, which can result as a consequence of femoral access or can occur spontaneously. This study aims to evaluate temporal changes in RH, its predictors, and clinical outcomes in a national cohort of patients undergoing percutaneous coronary intervention in the United Kingdom. METHODS AND RESULTS: We analyzed RH events in patients who underwent percutaneous coronary intervention between 2007 and 2014. Multiple logistic regression models were used to identify factors associated with RH and to quantify the association between RH and 30-day mortality and major adverse cardiovascular events. A total of 511 106 participants were included, and 291 in hospital RH events were recorded (0.06%). Overall, rates of RH declined from 0.09% to 0.03% between 2007 and 2014. The strongest independent predictors of RH events were femoral access (odds ratio [OR], 19.66; 95% confidence interval [CI], 11.22-34.43), glycoprotein IIb/IIIa inhibitor (OR, 2.63; 95% CI, 1.99-3.47), and warfarin use (OR, 2.53; 95% CI, 1.07-5.99). RH was associated with a significant increase in 30-day mortality (OR, 3.59; 95% CI, 2.19-5.90) and in-hospital major adverse cardiovascular events (OR, 5.76; 95% CI, 3.71-8.95). A legacy effect was not observed; patients with RH who survived 30 days did not have higher 1-year mortality compared with those without this complication (hazard ratio, 0.97; 95% CI, 0.49-1.91). CONCLUSIONS: Our results suggest that RH is a rare event that is declining in the United Kingdom, related to transition to transradial access site utilization, but remains a clinically important event associated with increased 30-day mortality but no long-term legacy effect.

Citation

Kontopantelis, E., Kinnaird, T., Potts, J., Rashid, M., Shoaib, A., Nolan, J., …Cardiovascular Intervention Society (BCIS) and National, B. (2018). Retroperitoneal Hemorrhage After Percutaneous Coronary Intervention: Incidence, Determinants, and Outcomes as Recorded by the British Cardiovascular Intervention Society. Circulation: Cardiovascular Interventions, 11(2), Article e005866. https://doi.org/10.1161/CIRCINTERVENTIONS.117.005866

Journal Article Type Article
Acceptance Date Dec 14, 2017
Publication Date Feb 14, 2018
Journal Circulation: Cardiovascular Interventions
Print ISSN 1941-7640
Publisher American Heart Association
Peer Reviewed Peer Reviewed
Volume 11
Issue 2
Article Number e005866
DOI https://doi.org/10.1161/CIRCINTERVENTIONS.117.005866
Keywords hemorrhage; incidence; mortality; percutaneous coronary intervention; warfarin
Publisher URL http://circinterventions.ahajournals.org/content/11/2/e005866