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Microwave Assisted Synthesis of Novel Bis-Flavone Dimers as New Anticancer Agents

McGown, Andrew; Ragazzon-Smith, Abby; Hadfield, John A.; Potgetier, Herman; Ragazzon, Patricia A.


Andrew McGown

Abby Ragazzon-Smith

John A. Hadfield

Herman Potgetier

Patricia A. Ragazzon


In this study we describe a microwave based click chemistry method used to prepare a family of novel bis-flavone dimers. The substituted 7-hydroxy and 4’-hydroxy flavonoids were linked through a triazole ring. The compounds were easily synthesized and purified in high yields. The bis-flavonoids were tested on different cell lines including HCT116, HepG2, MCF7 and MOLT-4. Several analogues showed to have anticancer activity with IC50 values in the range of 20-60 µM. Flavonoids are known for their anticancer properties and this method provides the basis for new medicinal structures.

Journal Article Type Article
Acceptance Date Jun 14, 2018
Publication Date Jan 1, 2019
Journal Letters in Organic Chemistry
Print ISSN 1570-1786
Publisher Bentham Science Publishers
Peer Reviewed Peer Reviewed
Volume 16
Issue 1
Pages 66-75
Keywords Flavonoid; bis-flavonoid; green-chemistry; click-chemistry; microwave-assisted chemistry; anticancer
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