Microwave Assisted Synthesis of Novel Bis-Flavone Dimers as New Anticancer Agents
McGown, Andrew; Ragazzon-Smith, Abby; Hadfield, John A.; Potgetier, Herman; Ragazzon, Patricia A.
John A. Hadfield
Patricia A. Ragazzon
In this study we describe a microwave based click chemistry method used to prepare a family of novel bis-flavone dimers. The substituted 7-hydroxy and 4’-hydroxy flavonoids were linked through a triazole ring. The compounds were easily synthesized and purified in high yields. The bis-flavonoids were tested on different cell lines including HCT116, HepG2, MCF7 and MOLT-4. Several analogues showed to have anticancer activity with IC50 values in the range of 20-60 µM. Flavonoids are known for their anticancer properties and this method provides the basis for new medicinal structures.
|Journal Article Type||Article|
|Acceptance Date||Jun 14, 2018|
|Publication Date||Jan 1, 2019|
|Journal||Letters in Organic Chemistry|
|Publisher||Bentham Science Publishers|
|Peer Reviewed||Peer Reviewed|
|Keywords||Flavonoid; bis-flavonoid; green-chemistry; click-chemistry; microwave-assisted chemistry; anticancer|
You might also like
Toxicological and Analytical Assessment of E-Cigarette Refill Components on Airway Epithelia
Facile synthesis and biological evaluation of chrysin derivatives