An open-source approach to automation in organic synthesis: The flow chemical formation of benzamides using an inline liquid-liquid extraction system and a homemade 3-axis autosampling/product-collection device

Abstract

Several open-source hardware and software technologies (RAMPS, Python, PySerial, OpenCV) were used to control an automated flow chemical synthesis system. The system was used to effect the synthesis of a series of benzamides. An inexpensive Raspberry Pi single board computer provided an electronic interface between the control computer and the RAMPS motor driver boards.

• Acceptance Date: Feb 19, 2018
• Publication Date: Feb 21, 2018
• Journal: Tetrahedron
• Print ISSN: 0040-4020
• Publisher: Elsevier
• DOI: https://doi.org/10.1016/j.tet.2018.02.043
• Keywords: Low-cost-automation; Open-source; Python; OpenCV; Raspberry-Pi; Flow-chemistry; Amide-formation; Liquid-liquid extraction
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S0040402018301881