Saeed Farooq s.farooq@keele.ac.uk
Barriers to using clozapine in treatment-resistant schizophrenia: systematic review
Farooq
Authors
Abstract
Aims and method
To systematically review the literature on barriers to the use of clozapine and identify any interventions for optimizing clozapine use in treatment-resistant schizophrenia. Journal databases were searched from 1972 to March 2018. The following search terms were used: treatment-resistant schizophrenia, clozapine, barriers, use, prescription rates, implementation, clozaril and prescribing practices. Following a review of the literature, 15 papers were included in the review.
RESULTS: The major barriers that were identified included mandatory blood testing, fear of serious side-effects and lack of adherence by the patients, difficulty in identifying suitable patients, service fragmentation, and inadequate training in or exposure to using clozapine.
Clinical implications
In view of consistent evidence across the studies on inadequate knowledge and skills as a significant barrier, we suggest that a certification requiring competence in initiating and managing side-effects of clozapine becomes a mandatory requirement in training programmes.
Declarations of interest
None.
Citation
Farooq. (2019). Barriers to using clozapine in treatment-resistant schizophrenia: systematic review. BJPsych Bulletin, 8-16. https://doi.org/10.1192/bjb.2018.67
Acceptance Date | Jul 12, 2018 |
---|---|
Publication Date | Feb 1, 2019 |
Journal | BJPsych Bulletin |
Print ISSN | 2056-4694 |
Publisher | Royal College of Psychiatrists |
Pages | 8-16 |
DOI | https://doi.org/10.1192/bjb.2018.67 |
Keywords | Treatment resistant schizophrenia, barriers, clozapine |
Publisher URL | https://www.cambridge.org/core/journals/bjpsych-bulletin/article/barriers-to-using-clozapine-in-treatmentresistant-schizophrenia-systematic-review/79562104DDA1F8FDCF8CBA551EECFC85 |
Files
S Farooq - Barrier to using clozapine.pdf
(710 Kb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
You might also like
PROF. MUHAMMAD SHAFIQUE (1936-2022): PIONEER OF PSYCHIATRY IN KHYBER PAKHTUNKHWA, PAKISTAN
(2022)
Journal Article
Downloadable Citations
About Keele Repository
Administrator e-mail: research.openaccess@keele.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search