The triglyceride glucose index can predict newly diagnosed biopsy-proven diabetic nephropathy in type 2 diabetes: A nested case control study

Simmons, D; Shang, J; Yu, D; Cai, Y; Wang, Z; Zhao, B; Zhao, Z

Abstract

Insulin resistance is usually a key factor in the development of type 2 diabetes. The triglyceride glucose (TyG) index is a marker of insulin resistance which is also implicated in the risk of nephropathy among people with type 2 diabetes. This study aimed to examine associations and potential thresholds between TyG index and the risk of newly diagnosed biopsy-proven diabetic nephropathy in people with type 2 diabetes. A nested case–control study incorporating 950 incident biopsy-proven diabetic nephropathy cases and age, gender matched 4750 patients with treated type 2 diabetes as controls selected by risk-set sampling method was implemented. The dose–response association between TyG index with subsequent risk of newly diagnosed biopsy-proven diabetic nephropathy after adjustment for age, gender, blood pressure, and other major cardiovascular risk factors were examined by conditional logistic regression model. A non-linear relationship was identified between TyG index and the risk of newly diagnosed biopsy-proven diabetic nephropathy with a potential threshold of TyG at 9.05–9.09. Similar relationships with the same threshold were also found in the analyses by fasting glucose and triglyceride levels. TyG index might be a prognostic factor in predicting newly development of biopsy-proven diabetic nephropathy among patients with treated type 2 diabetes. In people with type 2 diabetes, TyG index above 9.05–9.09 could be a prognostic threshold to identify individuals at high risk of diabetic nephropathy. Further replication studies are warranted.

Citation

Simmons, D., Shang, J., Yu, D., Cai, Y., Wang, Z., Zhao, B., & Zhao, Z. (2019). The triglyceride glucose index can predict newly diagnosed biopsy-proven diabetic nephropathy in type 2 diabetes: A nested case control study. Medicine, 98(46), 1-7. https://doi.org/10.1097/md.0000000000017995

• Journal Article Type: Article
• Acceptance Date: Oct 18, 2019
• Publication Date: Nov 14, 2019
• Journal: Medicine
• Print ISSN: 0025-7974
• Electronic ISSN: 1536-5964
• Publisher: Lippincott, Williams & Wilkins
• Peer Reviewed: Peer Reviewed
• Volume: 98
• Issue: 46
• Article Number: e17995
• Pages: 1-7
• DOI: https://doi.org/10.1097/md.0000000000017995
• Keywords: diabetes, diabetic retinopathy, insulin resistance, prognosis, TyG index
• Publisher URL: http://doi.org/10.1097/MD.0000000000017995
• PMID: 31725665