The global migration of Filipino nurses has received significant attention, yet little is known of these healthcare workers’ experiences and mobilities within the Philippines. I explore the experiences and narratives of Filipino nurses living in Manila, some of whom have no desires to migrate. I uncover the often novel forms of therapeutic mobilities undertaken by these nurses, focusing on call centre nursing and entrepreneurship as key alternative career pathways within the realms of ‘therapeutics’. Through interrogating the various mobilities undertaken by nurses – physical mobilities and migration, socioeconomic mobilities and occupational mobilities in the form of a career change – it becomes clear that international physical mobility is no longer key. Nevertheless, Filipino nurses continue to provide care in global contexts in novel ‘therapeutic’ industries and doing so allows them to increase their socioeconomic mobility.