New horizons in evidence-based care for older people: individual participant data meta-analysis

Clegg, A; Bandeen-Roche, K; Farrin, A; Forster, A; Gill, TM; Gladman, J; Kerse, N; Lindley, R; McManus, RJ; Melis, R; Mujica-Mota, R; Raina, P; Rockwood, K; Teh, R; Van Der Windt, D; Witham, M

Abstract

Evidence-based decisions on clinical and cost-effectiveness of interventions are ideally informed by meta-analyses of intervention trial data. However, when undertaken, such meta-analyses in ageing research have typically been conducted using standard methods whereby summary (aggregate) data are extracted from published trial reports. Although meta-analysis of aggregate data can provide useful insights into the average effect of interventions within a selected trial population, it has limitations regarding robust conclusions on which subgroups of people stand to gain the greatest benefit from an intervention or are at risk of experiencing harm. Future evidence synthesis using individual participant data from ageing research trials for meta-analysis could transform understanding of the effectiveness of interventions for older people, supporting evidence-based and sustainable commissioning. A major advantage of individual participant data meta-analysis (IPDMA) is that it enables examination of characteristics that predict treatment effects, such as frailty, disability, cognitive impairment, ethnicity, gender and other wider determinants of health. Key challenges of IPDMA relate to the complexity and resources needed for obtaining, managing and preparing datasets, requiring a meticulous approach involving experienced researchers, frequently with expertise in designing and analysing clinical trials. In anticipation of future IPDMA work in ageing research, we are establishing an international Ageing Research Trialists collective, to bring together trialists with a common focus on transforming care for older people as a shared ambition across nations.

Citation

Clegg, A., Bandeen-Roche, K., Farrin, A., Forster, A., Gill, T., Gladman, J., …Witham, M. (2022). New horizons in evidence-based care for older people: individual participant data meta-analysis. Age and ageing, 51(4), https://doi.org/10.1093/ageing/afac090

• Journal Article Type: Article
• Acceptance Date: Apr 1, 2022
• Publication Date: Apr 22, 2022
• Journal: Age and Ageing
• Print ISSN: 0002-0729
• Publisher: Oxford University Press
• Peer Reviewed: Peer Reviewed
• Volume: 51
• Issue: 4
• DOI: https://doi.org/10.1093/ageing/afac090
• Keywords: ageing, frailty, stratified care, individual participant data, meta-analysis, older people
• Publisher URL: https://academic.oup.com/ageing/article/51/4/afac090/6572255#350261578