Valorization of Hesperidin from Citrus Residues: Evaluation of Microwave-Assisted Synthesis of Hesperidin-Mg Complex and Their Insecticidal Activity

da Silva, DF; Bomfim, JPA; Marchi, RC; Amaral, JC; Pinto, LS; de Oliveira, RC; Buss, D; Kirk, W; Bruce, T; da Silva, MFGF; Carlos, RM; Ferreira, AG; Forim, MR; Fernandes, JB

Abstract

The aim of the current study was the valorization of hesperidin, the dominant flavonoid in citrus processing waste, by microwave-assisted synthesis of hesperidin-Mg complex, improving its antioxidant activity and insecticidal potential. Here we show, for the first time, that microwaveassisted synthesis of [Mg(hesp)2(phen)]OAc (1) (hesp: hesperidin, phen: phenanthroline) improve the reaction rate and yield. The nuclear magnetic resonance (NMR) experiments proved to be powerful tools for the identification of three isomers in metal complexes. Moreover, we explore the insecticidal potential of 1 and [Mg(phen)2(Isov)]OAc (2) (Isov : isovanillic acid) complexes against three insects. Complex 1 killed 80% of adults whitefly at 0.14 µmol L-1, and 2 76% at 0.36 µmol L-1. There was a total mortality of Spodoptera frugiperda with 2 at 0.39 µmol L-1, and 83% with 1 at 0.14 µmol L-1. Both have similar activity, and represent a novel group of insecticide for Bemisia tabaci and S. frugiperda; nevertheless, the benefits of both as Myzus persicae repellent require further evaluation.

Citation

da Silva, D., Bomfim, J., Marchi, R., Amaral, J., Pinto, L., de Oliveira, R., …Fernandes, J. (2022). Valorization of Hesperidin from Citrus Residues: Evaluation of Microwave-Assisted Synthesis of Hesperidin-Mg Complex and Their Insecticidal Activity

• Acceptance Date: Jun 17, 2022
• Publication Date: Jun 17, 2022
• Journal: JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
• Print ISSN: 0103-5053
• Pages: 772 - 782
• Keywords: Citrus; citrus waste; hesperidin; magnesium; microwave
• Publisher URL: http://static.sites.sbq.org.br/jbcs.sbq.org.br/pdf/2021-0434AR_ChemSustainDev.pdf