Management of Psoriatic Arthritis in Patients With Comorbidities: An Updated Literature Review Informing the 2021 GRAPPA Treatment Recommendations

Campanholo, Cristiano B.; Maharaj, Ajesh B.; Corp, Nadia; Bell, Stacie; Costa, Luisa; de Vlam, Kurt; Gullick, Nicola J.; Khraishi, Majed; Kishimoto, Mitsumasa; Palmou-Fontana, Natalia; Reddy, Soumya; Scarpa, Raffaele; Vega, Luis; Vieira Duarte, Gleison; Zisman, Devy; van der Windt, Danielle A.; Duruoz, Mehmet T.; Ogdie, Alexis

Abstract

Objective: The 2021 Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) treatment recommendations provide an evidence-based guide for selecting therapy based on the individual’s disease features. Beyond the disease features and associated conditions (eg, uveitis and inflammatory bowel disease), comorbidities play an important role in selecting therapy for an individual patient.

Methods: We performed a systematic literature review. We examined the available evidence to inform treatment selection based on the presence or absence of comorbidities in psoriatic arthritis (PsA).

Results: Common comorbidities in PsA that may affect treatment selection include presence of baseline cardiovascular disease (CVD) or high risk for CVD, obesity and metabolic syndrome, liver disease, mood disorders, including depression in particular, chronic infections, malignancies, osteoporosis, and fibromyalgia and/or central sensitization.

Conclusion: Comorbidities may influence both the effectiveness of a given therapy but also the potential for adverse events. It is important to assess for the presence of comorbidities prior to therapy selection.

Citation

Campanholo, C. B., Maharaj, A. B., Corp, N., Bell, S., Costa, L., de Vlam, K., …Ogdie, A. (2022). Management of Psoriatic Arthritis in Patients With Comorbidities: An Updated Literature Review Informing the 2021 GRAPPA Treatment Recommendations. The Journal of Rheumatology, 50(3), 426 - 432. https://doi.org/10.3899/jrheum.220310

• Journal Article Type: Article
• Acceptance Date: Aug 16, 2022
• Online Publication Date: Mar 1, 2023
• Publication Date: Nov 1, 2022
• Publicly Available Date: May 30, 2023
• Journal: The Journal of Rheumatology
• Print ISSN: 0315-162X
• Electronic ISSN: 1499-2752
• Publisher: Journal of Rheumatology
• Peer Reviewed: Peer Reviewed
• Volume: 50
• Issue: 3
• Pages: 426 - 432
• DOI: https://doi.org/10.3899/jrheum.220310
• Keywords: comorbidities; GRAPPA; psoriatic arthritis; treatments
• Publisher URL: https://www.jrheum.org/content/50/3/426
• Additional Information: Copyright © 2023 by the Journal of Rheumatology; This is an Open Access article, which permits use, distribution, and reproduction, without modification, provided the original article is correctly cited and is not used for commercial purposes.