Outcomes with catheter-directed thrombolysis vs. catheter-directed embolectomy among patients with high-risk pulmonary embolism: a nationwide analysis

Sedhom, Ramy; Elbadawi, Ayman; Megaly, Michael; Athar, Ahmed; Bharadwaj, Aditya S; Prasad, Vinoy; Cameron, Scott J; Weinberg, Ido; Mamas, Mamas A; Messerli, Adrian W; Jaber, Wissam; Elgendy, Islam Y

Abstract

Aims To examine the shot-term outcomes with catheter-directed thrombolysis (CDT) vs. catheter-directed embolectomy (CDE) for high-risk pulmonary embolism (PE). Methods and results The Nationwide Readmissions Database was utilized to identify hospitalizations with high-risk PE undergoing CDE or CDT from 2016 to 2019. The main outcome was all-cause in-hospital mortality. Propensity score matching was used to compare the outcomes in both groups. Among 3216 high-risk PE hospitalizations undergoing catheter-directed interventions, 868 (27%) received CDE, 1864 (58%) received CDT, and 484 (15%) received both procedures. In the unadjusted analysis, the rate of all-cause in-hospital mortality was not different between CDE and CDT (39.6% vs. 34.2%, P = 0.07). After propensity score matching, there was no difference in the incidence of in-hospital mortality [adjusted odds ratio (aOR): 1.28, 95% confidence interval (CI): 0.95, 1.72, P = 0.10], intracranial haemorrhage (ICH) (adjusted OR 1.57, 95% CI: 0.75, 3.29, P = 0.23), or non-ICH bleeding (aOR: 1.17, 95% CI: 0.85, 1.62, P = 0.33). There were no differences in the length of stay, cost, and 30-day unplanned readmissions between both groups. Conclusion In this contemporary observational analysis of patients admitted with high-risk PE undergoing CDT or CDE, the rates of in-hospital mortality, ICH, and non-ICH bleeding events were not different.

Citation

Sedhom, R., Elbadawi, A., Megaly, M., Athar, A., Bharadwaj, A. S., Prasad, V., Cameron, S. J., Weinberg, I., Mamas, M. A., Messerli, A. W., Jaber, W., & Elgendy, I. Y. (2023). Outcomes with catheter-directed thrombolysis vs. catheter-directed embolectomy among patients with high-risk pulmonary embolism: a nationwide analysis. European Heart Journal: Acute Cardiovascular Care, 12(4), 224-231. https://doi.org/10.1093/ehjacc/zuad004

• Journal Article Type: Article
• Acceptance Date: Feb 2, 2023
• Online Publication Date: Feb 4, 2023
• Publication Date: 2023-04
• Journal: European Heart Journal. Acute Cardiovascular Care
• Print ISSN: 2048-8726
• Electronic ISSN: 2048-8734
• Publisher: SAGE Publications
• Volume: 12
• Issue: 4
• Pages: 224-231
• DOI: https://doi.org/10.1093/ehjacc/zuad004
• Keywords: Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine, General Medicine
• Public URL: https://keele-repository.worktribe.com/output/426549
• Publisher URL: https://academic.oup.com/ehjacc/article/12/4/224/7026146