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Impact of Sex on Clinical Outcomes in Patients undergoing Complex Percutaneous Coronary Angioplasty (from the e-ULTIMASTER Study)

Mamas

Authors



Abstract

Female gender has been shown to be associated with worse clinical outcomes after percutaneous coronary intervention (PCI). However, the impact of gender on the clinical outcomes of complex PCI is still poorly understood. This study examined the differences in patient and coronary lesion characteristics and longer-term clinical outcomes in male and female patients who underwent complex PCI. This was a sub-analysis of the e-ULTIMASTER study, which was a large, multicontinental, prospective, observational study enrolling 37,198 patients who underwent PCI with the Ultimaster stent. Patients who underwent complex PCI were stratified by gender. The primary outcome was target lesion failure at 12 months, defined as the composite of cardiac death, target vessel-related myocardial infarction, and clinically driven target lesion revascularization at 12 months. A total of 13,623 patients underwent complex procedures, of which 35.7% were women. Women were twice as likely as men to be aged >= 80 years (17.6% vs 9%, p <0.0001) and had a higher prevalence of cardiovascular risk factors. Women had fewer lesions treated than men (1.5 +/- 0.8 vs 1.6 +/- 0.8, p <0.0001) and fewer stents implanted (2.0 +/- 1.1 vs 2.1 +/- 1.1, p <0.0001). There was no statistically significant difference in clinical outcomes at 12 months between women and men. Event rates were comparable in women and men for target lesion failure (4.7% vs 4.3%, p = 0.30), target vessel failure (5.1% vs 4.9%, p = 0.73), and cardiac death (1.8% vs 1.7%, p = 0.80).In conclusion, our findings suggest no significant differences in clinical outcomes between women and men who underwent complex PCI. (c) 2022 Elsevier Inc. All rights reserved.

Citation

Mamas. (2022). Impact of Sex on Clinical Outcomes in Patients undergoing Complex Percutaneous Coronary Angioplasty (from the e-ULTIMASTER Study). American Journal of Cardiology, 186, 71 - 79. https://doi.org/10.1016/j.amjcard.2022.10.023

Acceptance Date Nov 8, 2022
Publication Date Nov 8, 2022
Journal The American Journal of Cardiology
Print ISSN 0002-9149
Electronic ISSN 1879-1913
Publisher Elsevier
Volume 186
Pages 71 - 79
DOI https://doi.org/10.1016/j.amjcard.2022.10.023
Publisher URL https://www.ajconline.org/article/S0002-9149(22)01118-3/fulltext