A Single Picture Explains Diversity of Hyperthermia Response of Magnetic Nanoparticles

Conde-Leboran, Ivan; Baldomir, Daniel; Martinez-Boubeta, Carlos; Chubykalo-Fesenko, Oksana; del Puerto Morales, María; Salas, Gorka; Cabrera, David; Camarero, Julio; Teran, Francisco J.; Serantes, David

Abstract

Progress in the design of nanoscale magnets for localized hyperthermia cancer therapy has been largely driven by trial-and-error approaches, for instance, by changing of the stoichiometry composition, size, and shape of the magnetic entities. So far, widely different and often conflicting heat dissipation results have been reported, particularly as a function of the nanoparticle concentration. Thus, achieving hyperthermia-efficient magnetic ferrofluids remains an outstanding challenge. Here we demonstrate that diverging heat-dissipation patterns found in the literature can be actually described by a single picture accounting for both the intrinsic magnetic features of the particles (anisotropy, magnetization) and experimental conditions (concentration, magnetic field). Importantly, this general magnetic-hyperthermia scenario also predicts a novel non-monotonic concentration dependence with optimum heating features, which we experimentally confirmed in iron oxide nanoparticle ferrofluids by fine-tuning the particle size. Overall, our approach implies a magnetic hyperthermia trilemma that may constitute a simple strategy for development of magnetic nanomaterials for optimal hyperthermia efficiency.

Citation

Conde-Leboran, I., Baldomir, D., Martinez-Boubeta, C., Chubykalo-Fesenko, O., del Puerto Morales, M., Salas, G., …Serantes, D. (2015). A Single Picture Explains Diversity of Hyperthermia Response of Magnetic Nanoparticles. Journal of Physical Chemistry C, 119(27), 15698-15706. https://doi.org/10.1021/acs.jpcc.5b02555

• Journal Article Type: Article
• Online Publication Date: Jun 24, 2015
• Publication Date: Jul 9, 2015
• Deposit Date: Jun 7, 2023
• Journal: The Journal of Physical Chemistry C
• Print ISSN: 1932-7447
• Electronic ISSN: 1932-7455
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• Volume: 119
• Issue: 27
• Pages: 15698-15706
• DOI: https://doi.org/10.1021/acs.jpcc.5b02555
• Keywords: Surfaces, Coatings and Films; Physical and Theoretical Chemistry; General Energy; Electronic, Optical and Magnetic Materials