BSA-coated magnetic nanoparticles for improved therapeutic properties

Aires, Antonio; Ocampo, Sandra M.; Cabrera, David; Cueva, Leonor de la; Salas, Gorka; Teran, Francisco J.; Cortajarena, Aitziber L.

Abstract

In recent years, magnetic nanoparticles have been widely investigated due to their potential in biomedical applications. For successful in vivo applications, magnetic nanoparticles must satisfy several requirements such as biocompatibility, invisibility to the immune system, high colloidal stability in biological fluids, and long blood circulation times. In this study, we have developed a formulation in which the magnetic nanoparticles are coated with bovine serum albumin to provide enhanced colloidal stability in biological fluids preserving their magnetic properties. In addition, the nanoparticles carry a chemotherapeutic drug, showing their potential as drug delivery systems. Our results reveal the influence of protein adsorption on the colloidal stability and the dynamical magnetic response of functionalized magnetic nanoparticles. Moreover, cellular internalization and in vitro cytotoxic activity in Panc-1 pancreatic cancer cells reveal enhanced cellular internalization, successful intracellular drug delivery, and efficient anticancer activity.

Citation

Aires, A., Ocampo, S. M., Cabrera, D., Cueva, L. D. L., Salas, G., Teran, F. J., & Cortajarena, A. L. (2015). BSA-coated magnetic nanoparticles for improved therapeutic properties. Journal of Materials Chemistry B, 3(30), 6239-6247. https://doi.org/10.1039/c5tb00833f

• Journal Article Type: Article
• Acceptance Date: Jun 17, 2015
• Publication Date: Jun 17, 2015
• Deposit Date: Jun 8, 2023
• Journal: Journal of Materials Chemistry B
• Print ISSN: 2050-750X
• Electronic ISSN: 2050-7518
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 3
• Issue: 30
• Pages: 6239-6247
• DOI: https://doi.org/10.1039/c5tb00833f
• Keywords: General Materials Science; Biomedical Engineering; General Chemistry; General Medicine
• Additional Information: : This document is Similarity Check deposited; : Supplementary Information; : Aitziber L. Cortajarena (ResearcherID); : The Royal Society of Chemistry has an exclusive publication licence for this journal; OPEN ACCESS: The accepted version of this article will be made freely available after a 12 month embargo period; : Single-blind; : Received 5 May 2015; Accepted 17 June 2015; Accepted Manuscript published 17 June 2015; Advance Article published 2 July 2015; Version of Record published 22 July 2015