Editorial (Current and Emerging Pharmacological Therapies of Ischaemic Stroke)

Chen, Ruoli

Abstract

Stroke is a form of cardiovascular disease affecting blood supply to the brain. About 87% of strokes are ischemic, and the remainder are haemorrhagic. Ischaemic stroke is caused by the obstruction of blood flow in a brain artery leading to the lack of oxygen and glucose supply to the brain region, resulting in the collapse of oxidative metabolism, decreased ATP synthesis, increased free radical production, unregulated influx of calcium/sodium and membrane depolarization, and calcium excitotoxicity. Eventually, cerebral ischaemia leads to formation of an “unviable” core and damaged but “amenable” penumbral regions.

Citation

Chen, R. (2013). Editorial (Current and Emerging Pharmacological Therapies of Ischaemic Stroke). CNS and Neurological Disorders - Drug Targets, 12(2), 143-144. https://doi.org/10.2174/1871527311312020001

• Journal Article Type: Editorial
• Publication Date: Apr 1, 2013
• Deposit Date: Jun 8, 2023
• Journal: CNS & Neurological Disorders - Drug Targets
• Print ISSN: 1871-5273
• Publisher: Bentham Science Publishers
• Peer Reviewed: Peer Reviewed
• Volume: 12
• Issue: 2
• Pages: 143-144
• DOI: https://doi.org/10.2174/1871527311312020001
• Keywords: Pharmacology; General Neuroscience