Differences in concentration of metal debris in blood, serum, and plasma samples of patients with metal-on-metal hip resurfacing arthroplasty

Khan, M.; Kuiper, J.H.; Sieniawska, Christine; Richardson, J.B.

Abstract

Background/aims
Cobalt and chromium are released from MOM hips and their precise nature (ions/particles) is not known. Their distribution in serum, plasma, and whole blood may help to determine their nature.

Methods
We measured cobalt and chromium concentrations in plasma, serum, and whole blood samples of patients with resurfacing MOM hips.

Results
We found that chromium concentration was highest in plasma, followed by serum and whole blood. Chromium and cobalt concentrations were higher in serum and plasma, compared to whole blood.

Conclusion
We, therefore, suggest that in future cobalt and chromium concentrations shall be reported using plasma samples.

Citation

Khan, M., Kuiper, J., Sieniawska, C., & Richardson, J. (2016). Differences in concentration of metal debris in blood, serum, and plasma samples of patients with metal-on-metal hip resurfacing arthroplasty. Journal of Orthopaedics, 13(4), 450-454. https://doi.org/10.1016/j.jor.2015.10.006

• Journal Article Type: Article
• Acceptance Date: Oct 4, 2015
• Online Publication Date: Dec 9, 2015
• Publication Date: 2016-12
• Deposit Date: Jul 4, 2023
• Journal: Journal of Orthopaedics
• Print ISSN: 0972-978X
• Publisher: Calicut Medical College
• Peer Reviewed: Peer Reviewed
• Volume: 13
• Issue: 4
• Pages: 450-454
• DOI: https://doi.org/10.1016/j.jor.2015.10.006
• Keywords: Orthopedics and Sports Medicine; Metal ions; Serum; Plasma; Chromium; Cobalt
• Additional Information: This article is maintained by: Elsevier; Article Title: Differences in concentration of metal debris in blood, serum, and plasma samples of patients with metal-on-metal hip resurfacing arthroplasty; Journal Title: Journal of Orthopaedics; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.jor.2015.10.006; Content Type: article; Copyright: © 2015 Prof. PK Surendran Memorial Education Foundation. Published by Elsevier, a division of Reed Elsevier India, Pvt. Ltd. All rights reserved.