In Vivo Deep Tissue Fluorescence and Magnetic Imaging Employing Hybrid Nanostructures

Ortgies, Dirk H.; de la Cueva, Leonor; del Rosal, Blanca; Sanz-Rodríguez, Francisco; Fernández, Nuria; Iglesias-de la Cruz, M. Carmen; Salas, Gorka; Cabrera, David; Teran, Francisco J.; Jaque, Daniel; Martín Rodríguez, Emma

Abstract

Breakthroughs in nanotechnology have made it possible to integrate different nanoparticles in one single hybrid nanostructure (HNS), constituting multifunctional nanosized sensors, carriers, and probes with great potential in the life sciences. In addition, such nanostructures could also offer therapeutic capabilities to achieve a wider variety of multifunctionalities. In this work, the encapsulation of both magnetic and infrared emitting nanoparticles into a polymeric matrix leads to a magnetic-fluorescent HNS with multimodal magnetic-fluorescent imaging abilities. The magnetic-fluorescent HNS are capable of simultaneous magnetic resonance imaging and deep tissue infrared fluorescence imaging, overcoming the tissue penetration limits of classical visible-light based optical imaging as reported here in living mice. Additionally, their applicability for magnetic heating in potential hyperthermia treatments is assessed.

Citation

Ortgies, D. H., de la Cueva, L., del Rosal, B., Sanz-Rodríguez, F., Fernández, N., Iglesias-de la Cruz, M. C., …Martín Rodríguez, E. (2016). In Vivo Deep Tissue Fluorescence and Magnetic Imaging Employing Hybrid Nanostructures. ACS applied materials & interfaces, 8(2), 1406-1414. https://doi.org/10.1021/acsami.5b10617

• Journal Article Type: Article
• Online Publication Date: Jan 7, 2016
• Publication Date: Jan 20, 2016
• Deposit Date: Jun 12, 2023
• Journal: ACS Applied Materials & Interfaces
• Print ISSN: 1944-8244
• Electronic ISSN: 1944-8252
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• Volume: 8
• Issue: 2
• Pages: 1406-1414
• DOI: https://doi.org/10.1021/acsami.5b10617
• Keywords: General Materials Science