MicroRNAs in Cancer

Di Leva, Gianpiero; Garofalo, Michela; Croce, Carlo M.

Abstract

MicroRNAs (miRNAs) are small noncoding RNAs that typically inhibit the translation and stability of messenger RNAs (mRNAs), controlling genes involved in cellular processes such as inflammation, cell-cycle regulation, stress response, differentiation, apoptosis, and migration. Thus, miRNAs have been implicated in the regulation of virtually all signaling circuits within a cell, and their dysregulation has been shown to play an essential role in the development and progression of cancer. Here, after a brief description of miRNA genomics, biogenesis, and function, we discuss the effects of miRNA dysregulation in the cellular pathways that lead to the progressive conversion of normal cells into cancer cells and the potential to develop new molecular miRNA-targeted therapies.

Citation

Di Leva, G., Garofalo, M., & Croce, C. M. (2014). MicroRNAs in Cancer. Annual Review of Pathology: Mechanisms of Disease, 9(1), 287-314. https://doi.org/10.1146/annurev-pathol-012513-104715

• Journal Article Type: Article
• Publication Date: Jan 24, 2014
• Deposit Date: Jun 12, 2023
• Journal: Annual Review of Pathology: Mechanisms of Disease
• Print ISSN: 1553-4006
• Electronic ISSN: 1553-4014
• Publisher: Annual Reviews
• Peer Reviewed: Peer Reviewed
• Volume: 9
• Issue: 1
• Pages: 287-314
• DOI: https://doi.org/10.1146/annurev-pathol-012513-104715
• Keywords: Pathology and Forensic Medicine; microRNAs; miRs; noncoding RNAs; cancer