miRNA clusters as therapeutic targets for hormone-resistant breast cancer

Di Leva, Gianpiero; Cheung, Douglas G; Croce, Carlo M

Abstract

MicroRNAs are small non-coding RNAs that typically inhibit the translation and stability of messenger RNAs, controlling genes involved in cellular processes such as inflammation, cell cycle regulation, stress response, differentiation, apoptosis, and migration. Not surprisingly, microRNAs are also aberrantly expressed in cancer and promote tumorigenesis by disrupting these vital cellular functions. In this review, we first broadly summarize the role of microRNAs in breast cancer and Estrogen Receptor alpha signaling. Then we focus on what is currently known about the role of microRNAs in anti-hormonal therapy or resistance to endocrine agents. Specifically, we will discuss key miRNAs involved in tamoxifen (miR-221/222, 181, 101, 519a, 301, 375, 342, 451, and the let-7 family), fulvestrant (miR-221/222, miR-200 family), and aromatase inhibitor (miR-128 and the let-7 family) resistance.

Citation

Di Leva, G., Cheung, D. G., & Croce, C. M. (2015). miRNA clusters as therapeutic targets for hormone-resistant breast cancer. Expert Review of Endocrinology and Metabolism, 10(6), 607-617. https://doi.org/10.1586/17446651.2015.1099430

• Journal Article Type: Article
• Online Publication Date: Oct 13, 2015
• Publication Date: Nov 2, 2015
• Deposit Date: Jun 12, 2023
• Journal: Expert Review of Endocrinology & Metabolism
• Print ISSN: 1744-6651
• Electronic ISSN: 1744-8417
• Publisher: Taylor and Francis
• Peer Reviewed: Peer Reviewed
• Volume: 10
• Issue: 6
• Pages: 607-617
• DOI: https://doi.org/10.1586/17446651.2015.1099430
• Keywords: Endocrinology; Diabetes and Metabolism; microRNA; breast cancer; non-coding RNAs; endocrine therapy; endocrine therapy resistance; tamoxifen; fulvestrant; aromatase inhibitor; estrogen receptor
• Additional Information: Peer Review Statement: The publishing and review policy for this title is described in its Aims & Scope.; Aim & Scope: http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=iere20