New strategies for the treatment of ovarian cancer

Robinson, Elizabeth; Fisher, Natalie; Stamelos, Vasileios; Redman, Charles; Richardson, Alan

Abstract

Ovarian cancer usually responds well to chemotherapy, but once the disease becomes resistant to chemotherapy, the treatment options available are inadequate. A number of strategies are currently undergoing clinical evaluation, among which angiogenesis and PARP [poly(ADP-ribose) polymerase] inhibitors appear promising. Pre-clinical studies have identified several potential new therapeutic strategies, and we review the potential for use of BH3 (Bcl-2 homology) mimetics, autotaxin inhibitors and statins to treat ovarian cancer.

• Journal Article Type: Article
• Online Publication Date: Jan 23, 2014
• Publication Date: Feb 1, 2014
• Deposit Date: Jun 12, 2023
• Journal: Biochemical Society Transactions
• Print ISSN: 0300-5127
• Electronic ISSN: 1470-8752
• Publisher: Portland Press
• Peer Reviewed: Peer Reviewed
• Volume: 42
• Issue: 1
• Pages: 125-129
• DOI: https://doi.org/10.1042/bst20130203
• Keywords: Biochemistry; apoptosis; autotaxin; BH3 mimetic (Bcl-2 homology domain 3 mimetic); ovarian cancer; statin