Potential use of hybrid iron oxide gold nanoparticles as drug carriers

Curtis, Anthony; Hoskins, Clare

Abstract

Hybrid nanoparticles are composed of more than one material fused together to increase functionality. These often consist of polymers coated onto the surface of metallic nanoparticles to render them useful in biomedicine [1,2]. In this chapter the term hybrid nanoparticles refers to an iron oxide core surrounded by a gold coat [3]. Iron oxide nanoparticles have been exploited clinically for their magnetic resonance (MR) properties and imaging capabilities. Traditionally iron oxide contrast agents used clinically for MR imaging (MRI) were composed of a dense metallic core surrounded by either a dextran or carboxydextran polymer shell (Feridex® and Resovist® respectively) (Figure 1). However, safety concerns over the degradation of the iron core into toxic free radicals led to their removal from clinical use in humans in the UK [4].

Citation

Curtis, A., & Hoskins, C. Potential use of hybrid iron oxide gold nanoparticles as drug carriers. In Nano Based Drug Delivery (535-546). IAPC Publishing (International Association of Physical Chemists). https://doi.org/10.5599/obp.8.21

• Online Publication Date: Jul 21, 2015
• Deposit Date: Jun 12, 2023
• Publisher: IAPC Publishing (International Association of Physical Chemists)
• Pages: 535-546
• Book Title: Nano Based Drug Delivery
• Chapter Number: 21
• DOI: https://doi.org/10.5599/obp.8.21
• Publisher URL: http://iapc-obp.com/books/release_detail/8