Synthesis of 3-Amino-2-carboxamide Tetrahydropyrrolo[2,3-b]quinolines

Barker, David; Pilkington, Lisa; Haverkate, Natalie; van Rensburg, Michelle; Reynisson, Johannes; Leung, Euphemia

Abstract

This article communicates the first synthesis of 3-amino-2-carboxamide pyrrolo[2,3-b]quinolines and fused-ring pyrrolopyridines in an efficient synthesis via a Thorpe–Ziegler transformation. The reported synthetic route allows for a wide range of nitrogen analogues of thienopyridines – compounds which have potent bioactivities but poor aqueous solubility.

Citation

Barker, D., Pilkington, L., Haverkate, N., van Rensburg, M., Reynisson, J., & Leung, E. (in press). Synthesis of 3-Amino-2-carboxamide Tetrahydropyrrolo[2,3-b]quinolines. SYNLETT, 27(20), 2811-2814. https://doi.org/10.1055/s-0036-1588619

• Journal Article Type: Article
• Acceptance Date: Sep 13, 2016
• Online Publication Date: Oct 11, 2016
• Deposit Date: Jun 13, 2023
• Journal: Synlett
• Print ISSN: 0936-5214
• Electronic ISSN: 1437-2096
• Publisher: Thieme Gruppe
• Peer Reviewed: Peer Reviewed
• Volume: 27
• Issue: 20
• Pages: 2811-2814
• DOI: https://doi.org/10.1055/s-0036-1588619
• Keywords: Organic Chemistry