RISK OF VENOUS THROMBOEMBOLISM AFTER GOUT FLARES

Cipolletta, E.; Nakafero, G.; Mamas, M.; Avery, A.; Tata, L.; Abhishek, A.

Abstract

Background Several population-based cohort studies have reported an increased risk of venous thromboembolism (VTE) in gout patients. However, none of these studies has investigated the temporal relationship between gout flares and VTE.

Objectives To explore whether gout flares increase the risk of VTE in the short-term using the self-controlled case series (SCCS) method.

Methods We identified participants with incident gout from the Clinical Practice Research Datalink (CPRD). Participants having less than one year of registration in CPRD and patients with a history of VTE or anticoagulant prescription more than one year before the first gout consultation were excluded.

Participants with at least one gout flare and a diagnosis of VTE were selected. VTEs and gout flares were ascertained using primary care data, hospitalisation and mortality records, using previously validated algorithms (positive predictive value of 94% for VTE [1] and 68-95% for gout flares [2,3]).

SCCS method involves fitting a Poisson model conditioned on the number of VTEs, and it calculates the adjusted incidence risk ratio (aIRR) and its 95% confidence interval (95%CI) for each stratum of the “at-risk” period as compared with the “baseline” period (Figure 1). The analysis was adjusted for age and calendar season.

Citation

Cipolletta, E., Nakafero, G., Mamas, M., Avery, A., Tata, L., & Abhishek, A. (2022, June). RISK OF VENOUS THROMBOEMBOLISM AFTER GOUT FLARES. Poster presented at EULAR 2022 European Congress of Rheumatology, Copenhagen, Denmark

• Presentation Conference Type: Poster
• Conference Name: EULAR 2022 European Congress of Rheumatology
• Conference Location: Copenhagen, Denmark
• Start Date: Jun 1, 2022
• End Date: Jun 4, 2022
• Deposit Date: Jun 26, 2023
• Publisher: BMJ Publishing Group
• DOI: https://doi.org/10.1136/annrheumdis-2022-eular.4633