Prognostic significance of early urinary catheterization after acute stroke: Secondary analyses of the international HeadPoST trial

Ouyang, Menglu; Billot, Laurent; Song, Lili; Wang, Xia; Roffe, Christine; Arima, Hisatomi; Lavados, Pablo M.; Hackett, Maree L.; Olavarria, Veronica V.; Munoz-Venturelli, Paula; Middleton, Sandy; Pontes-Neto, Octavio M.; Lee, Tsong-Hai; Watkins, Caroline L.; Robinson, Thompson G.; Anderson, Craig S.

Abstract

Background
An indwelling urinary catheter (IUC) is often inserted to manage bladder dysfunction, but its impact on prognosis is uncertain. We aimed to determine the association of IUC use on clinical outcomes after acute stroke in the international, multi-center, cluster crossover, Head Positioning in Acute Stroke Trial (HeadPoST).
Methods
Data were analyzed on HeadPoST participants (n = 11,093) randomly allocated to the lying-flat or sitting-up head position. Binomial, logistic regression, hierarchical mixed models were used to determine associations of early insertion of IUC within seven days post-randomization and outcomes of death or disability (defined as “poor outcome,” scores 3–6 on the modified Rankin scale) and any urinary tract infection at 90 days with adjustment of baseline and post-randomization management covariates.
Results
Overall, 1167 (12%) patients had an IUC, but the frequency and duration of use varied widely across patients in different regions. IUC use was more frequent in older patients, and those with vascular comorbidity, greater initial neurological impairment (on the National Institutes of Health Stroke Scale), and intracerebral hemorrhage as the underlying stroke type. IUC use was independently associated with poor outcome (adjusted odds ratio (aOR): 1.40, 95% confidence interval (CI): 1.13–1.74), but not with urinary tract infection after adjustment for antibiotic treatment and stroke severity at hospital separation (aOR: 1.13, 95% CI: 0.59–2.18). The number exposed to IUC for poor outcome was 13.
Conclusions
IUC use is associated with a poor outcome after acute stroke. Further studies are required to inform appropriate use of IUC.

Citation

Ouyang, M., Billot, L., Song, L., Wang, X., Roffe, C., Arima, H., …Anderson, C. S. (2021). Prognostic significance of early urinary catheterization after acute stroke: Secondary analyses of the international HeadPoST trial. International Journal of Stroke, 16(2), 200-206. https://doi.org/10.1177/1747493020908140

• Journal Article Type: Article
• Acceptance Date: Oct 14, 2019
• Online Publication Date: Feb 19, 2020
• Publication Date: 2021-02
• Deposit Date: Jun 26, 2023
• Journal: INTERNATIONAL JOURNAL OF STROKE
• Print ISSN: 1747-4930
• Publisher: SAGE Publications
• Peer Reviewed: Peer Reviewed
• Volume: 16
• Issue: 2
• Article Number: ARTN 1747493020908140
• Pages: 200-206
• DOI: https://doi.org/10.1177/1747493020908140
• Keywords: Urinary catheter, disability, acute stroke, urinary tract infection, clinical trial