The Mitochondria: A Target of Polyphenols in the Treatment of Diabetic Cardiomyopathy

Bhagani, Humna; Nasser, Suzanne A.; Dakroub, Ali; El-Yazbi, Ahmed F.; Eid, Assaad A.; Kobeissy, Firas; Pintus, Gianfranco; Eid, Ali H.

Abstract

Diabetic cardiomyopathy (DCM) is a constellation of symptoms consisting of ventricular dysfunction and cardiomyocyte disarray in the presence of diabetes. The exact cause of this type of cardiomyopathy is still unknown; however, several processes involving the mitochondria, such as lipid and glucose metabolism, reactive oxygen species (ROS) production, apoptosis, autophagy and mitochondrial biogenesis have been implicated. In addition, polyphenols have been shown to improve the progression of diabetes. In this review, we discuss some of the mechanisms by which polyphenols, particularly resveratrol, play a role in slowing the progression of DCM. The most important intermediates by which polyphenols exert their protective effect include Bcl-2, UCP2, SIRT-1, AMPK and JNK1. Bcl-2 acts to attenuate apoptosis, UCP2 decreases oxidative stress, SIRT-1 increases mitochondrial biogenesis and decreases oxidative stress, AMPK increases autophagy, and JNK1 decreases apoptosis and increases autophagy. Our dissection of these molecular players aims to provide potential therapeutic targets for the treatment of DCM.

Citation

Bhagani, H., Nasser, S. A., Dakroub, A., El-Yazbi, A. F., Eid, A. A., Kobeissy, F., Pintus, G., & Eid, A. H. (2020). The Mitochondria: A Target of Polyphenols in the Treatment of Diabetic Cardiomyopathy. International Journal of Molecular Sciences, 21(14), Article ARTN 4962. https://doi.org/10.3390/ijms21144962

• Journal Article Type: Article
• Acceptance Date: Jul 8, 2020
• Online Publication Date: Jul 14, 2020
• Publication Date: Jul 14, 2020
• Deposit Date: Jun 28, 2023
• Journal: International Journal of Molecular Sciences
• Print ISSN: 1661-6596
• Electronic ISSN: 1422-0067
• Publisher: MDPI
• Peer Reviewed: Peer Reviewed
• Volume: 21
• Issue: 14
• Article Number: ARTN 4962
• DOI: https://doi.org/10.3390/ijms21144962
• Keywords: diabetic cardiomyopathy; polyphenols; resveratrol; autophagy
• Public URL: https://keele-repository.worktribe.com/output/509897