The Peritoneal Dialysis Outcomes and Practice Patterns Study

Stallard, Belinda; Johnson, David W.; Perl, Jeffrey; Davies, Simon J.

Abstract

Background: Peritoneal dialysis (PD) technique failure remains a significant barrier to improving the outcomes for PD patients and increasing the uptake of PD worldwide. The Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) has been developed to identify variations in clinical practices and potentially modifiable causes of technique failure with the objective to improve PD outcomes.

Methods: PDOPPS is a prospective cohort study initially involving seven different countries such as Australia, New Zealand, Canada, Japan, Thailand, the United Kingdom, and the United States. The primary outcome is all-cause PD technique failure, and the secondary outcomes include hospitalization rates, PD-related all-cause mortality, PD-related complications, cause-specific technique failure, and patient-reported outcomes.

Results: The PDOPPS clinical workgroups have collaborated to design, analyze, and publish several clinically relevant studies which focus on PD training and education, PD catheter access and function, infection prevention and management, patient support, dialysis prescription and fluid management, and clinical application of PD therapy. The common finding is of wide variations in clinical practice, not always aligned to international guidelines and differences in important outcomes known to impact technique failure.

Conclusion: The PDOPPS is an innovative, internationally collaborative research initiative which aims to advance the understanding in variations in PD practices and how these link to outcomes that are important to patients, with the overall goal of identifying optimal clinical practice, extending PD technique survival, and improving quality of life for PD patients.

• Online Publication Date: Jul 25, 2021
• Publication Date: 2021
• Deposit Date: Jun 28, 2023
• Publisher: Springer
• Pages: 395-410
• Book Title: Applied Peritoneal Dialysis
• Chapter Number: 28
• ISBN: 9783030708962; 9783030708979
• DOI: https://doi.org/10.1007/978-3-030-70897-9_28
• Keywords: Center effect; Center size; Cohort studies; International cooperation; Kidney failure; Outcomes; Peritoneal dialysis, Peritonitis; Practice patterns; Treatment failure
• Additional Information: First Online: 25 July 2021