M Mohamed
Trends of sex differences in outcomes of cardiac electronic device implantations in the United States
Mohamed, M; Volgman, A.S; Contractor, T; Sharma, P.S; Kwok, C.S; Martin, G.P; Barker, D; Patwala, A; Mamas, M.A
Authors
A.S Volgman
T Contractor
P.S Sharma
C.S Kwok
G.P Martin
D Barker
A Patwala
Mamas Mamas m.mamas@keele.ac.uk
Abstract
Background
There is limited evidence on the differences in procedural outcomes between sexes after de novo cardiac implantable electronic device implantation (CIED). Furthermore, it is unclear whether any sex-based disparities have changed over the years.
Purpose
To compare procedural outcomes of de novo CIED implantation between sexes and study the trends of these outcomes over a 11-year period in a nationally representative sample.
Methods
Using the National Inpatient Sample, all hospitalisations between 2004 and 2014 for de novo CIED implantation were included, stratified by sex. Multivariable logistic regression was performed to 1) examine the association between sex and in-hospital complications of CIED implantation, expressed as odds ratios (OR) with 95% confidence intervals (CI), and 2) analyse trends of in-hospital outcomes by assessing the interaction term between time (years) and sex as covariates.
Results
Out of 2,815,613 hospitalisations for de novo CIED implantation, 41.9% were performed on women. Women were associated with increased adjusted odds of major adverse cardiovascular events (composite of mortality, thoracic and cardiac complications; OR 1.17 95% CI 1.16, 1.19), procedure-related bleeding (OR 1.13 95% CI 1.12, 1.15), and local complications (thoracic: OR 1.42 95% CI 1.40, 1.44, cardiac: OR 1.44 95% CI 1.38, 1.50). (p<0.001 for all) Notably, there was no difference in odds of all-cause mortality between sexes (OR women: 0.96 95% CI 0.94, 1.00). The odds of adverse complications in the overall CIED cohort were persistently raised in women throughout the study period, whereas similar odds of all-cause mortality across the sexes were observed throughout the study period (see Figure).
Conclusion
In a national cohort of CIED implantations we demonstrate that women are at a persistently higher risk of procedure-related adverse events other than mortality compared to men. This trend is concerning and warrants further work on procedural techniques to neutralise these sex disparities.
Citation
Mohamed, M., Volgman, A., Contractor, T., Sharma, P., Kwok, C., Martin, G., …Mamas, M. (2020). Trends of sex differences in outcomes of cardiac electronic device implantations in the United States. European Heart Journal, 41(Supplement_2), https://doi.org/10.1093/ehjci/ehaa946.0831
Journal Article Type | Conference Paper |
---|---|
Conference Name | ESC Congress 2020 - The Digital Experience; 29 August - 1 September 2020 |
Conference Location | Virtual |
Online Publication Date | Nov 25, 2020 |
Publication Date | Nov 1, 2020 |
Deposit Date | Jun 28, 2023 |
Journal | European Heart Journal |
Print ISSN | 0195-668X |
Electronic ISSN | 1522-9645 |
Publisher | Oxford University Press |
Peer Reviewed | Peer Reviewed |
Volume | 41 |
Issue | Supplement_2 |
DOI | https://doi.org/10.1093/ehjci/ehaa946.0831 |
Keywords | Cardiology and Cardiovascular Medicine; Device Complications and Lead Extraction |
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