Effects of Valvular Heart Disease on Clinical Outcomes in Sarcoidosis.

Hussain, Bilal; Markson, Favour; Mamas, Mamas A; Alraies, Chadi; Aggarwal, Vikas; Kumar, Gautam; Desai, Rupak; Paul, Timir K

Abstract

Systemic sarcoidosis can lead to heart failure, conduction abnormalities and ventricular arrhythmias although data on concomitant valvular heart disease (VHD) is limited. We reported the prevalence and outcomes of VHD in systemic sarcoidosis. A retrospective cohort study was conducted using National Inpatient Sample between 2016-2020 with respective ICD-10-CM codes. 406,315 patients were hospitalized with sarcoidosis, out of which 20570 had comorbid VHD (5.1%). Mitral disease was most common (2.5%), followed by aortic, and tricuspid disease. Tricuspid disease was associated with increased mortality in sarcoidosis (OR 1.6, 95% CI 1.1-2.6, p=0.04), while aortic disease was associated with higher mortality in only 31-50 years age cohort. Patients with sarcoidosis and VHD have higher hospitalization charges and lower or similar valvular intervention rates than those without sarcoidosis. VHD has a prevalence of 5% in sarcoidosis, predominantly affecting mitral and aortic valves. Underlying VHD is associated with worse outcomes in sarcoidosis. [Abstract copyright: Copyright © 2023. Published by Elsevier Inc.]

Citation

Hussain, B., Markson, F., Mamas, M. A., Alraies, C., Aggarwal, V., Kumar, G., …Paul, T. K. (2023). Effects of Valvular Heart Disease on Clinical Outcomes in Sarcoidosis. Current Problems in Cardiology, 48(10), Article 101866. https://doi.org/10.1016/j.cpcardiol.2023.101866

• Journal Article Type: Article
• Acceptance Date: Jun 4, 2023
• Online Publication Date: Jun 8, 2023
• Publication Date: 2023-10
• Deposit Date: Jul 4, 2023
• Journal: Current problems in cardiology
• Print ISSN: 0146-2806
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 48
• Issue: 10
• Article Number: 101866
• DOI: https://doi.org/10.1016/j.cpcardiol.2023.101866
• Keywords: Aortic Valve Disease, Valvular Heart Disease, Tricuspid Valve Disease, Transcatheter Aortic Valve Replacement, Sarcoidosis