Impact of the COVID-19 Pandemic on Diabetes-Related Cardiovascular Mortality in the United States.

Bashar, Hussein; Kobo, Ofer; Khunti, Kamlesh; Sun, Louise Y; Rutter, Martin K; Chew, Nicholas W S; Curzen, Nick; Mamas, Mamas A

Abstract

Background In the past few decades, diabetes-related cardiovascular mortality has been steadily declining. However, the impact of the COVID19 pandemic on this trend has not been previously defined. Methods and Results Diabetes-related cardiovascular mortality data were extracted for each year between 1999 and 2020 from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (WONDER) database. Regression analysis was used to calculate the trend in the 2 decades before the pandemic (1999-2019) and thereby estimate the excess cardiovascular mortality in 2020. There was a 29.2% fall in the diabetes-related cardiovascular age-adjusted mortality rate between 1999 to 2019, largely driven by a 41% decrease in ischemic heart disease deaths. In comparison to 2019, there was an overall 15.5% increase in the diabetes-related cardiovascular age-adjusted mortality rate in the first year of the pandemic, mainly due to a 14.1% rise in ischemic heart disease deaths. Younger patients (under 55 years) and the Black population experienced the greatest increase in diabetes-related cardiovascular age-adjusted mortality rate (24.0% and 25.3%, respectively). Trend analysis estimated 16 009 excess diabetes-related cardiovascular deaths in 2020, with the majority due to ischemic heart disease (8504). Black and Hispanic or Latino populations had at least one-fifth of their 2020 diabetes-related cardiovascular age-adjusted mortality rate as excess deaths (22.3% and 20.2%, respectively). Conclusions There was a sharp rise in diabetes-related cardiovascular mortality during the first pandemic year. Black, Hispanic or Latino, and young people showed the largest increases in diabetes-related cardiovascular mortality. Targeted health policies could help address the disparities observed in this analysis.

Citation

Bashar, H., Kobo, O., Khunti, K., Sun, L. Y., Rutter, M. K., Chew, N. W. S., Curzen, N., & Mamas, M. A. (in press). Impact of the COVID-19 Pandemic on Diabetes-Related Cardiovascular Mortality in the United States. Journal of the American Heart Association, 12(13), e028896. https://doi.org/10.1161/JAHA.122.028896

• Journal Article Type: Article
• Acceptance Date: May 31, 2023
• Online Publication Date: Jun 29, 2023
• Deposit Date: Aug 1, 2023
• Journal: Journal of the American Heart Association
• Electronic ISSN: 2047-9980
• Publisher: Wiley Open Access
• Peer Reviewed: Peer Reviewed
• Volume: 12
• Issue: 13
• Pages: e028896
• DOI: https://doi.org/10.1161/JAHA.122.028896
• Keywords: Diabetes Mellitus - epidemiology, diabetes, COVID-19, Mortality, Cardiovascular Diseases, Humans, ischemic heart disease, Myocardial Ischemia, cardiovascular mortality, racial disparities, COVID‐19, United States - epidemiology, Adolescent, Pandemics, ischemic heart disease, cardiovascular mortality, diabetes, COVID‐19, racial disparities
• Public URL: https://keele-repository.worktribe.com/output/516888