Social disparities in cardiovascular mortality of patients with cancer in the USA between 1999 and 2019

Raisi-Estabragh, Zahra; Kobo, Ofer; López-Fernández, Teresa; Qadir, Husam Abdel; Chew, Nicholas WS.; Wojakowski, Wojtek; Abhishek, Abhishek; Miller, Robert J.H.; Mamas, Mamas A.

Abstract

Background
Temporal trends of the impact of social determinants on cardiovascular outcomes of cancer patients has not been previously studied.

Objectives
This study examined social disparities in cardiovascular mortality of people with and without cancer in the US population between 1999 and 2019.

Methods
Primary cardiovascular deaths were identified from the Multiple Cause of Death database and grouped by cancer status. The cancer cohort was subcategorized into breast, lung, prostate, colorectal, and haematological. The number of cardiovascular deaths, crude cardiovascular mortality rate, cardiovascular age-adjusted mortality rate (AAMR), and percentage change in cardiovascular AAMR were calculated by cancer status and cancer type, and stratified by sex, race, ethnicity, and urban-rural setting.

Results
17.9 million cardiovascular deaths were analysed. Of these, 572,222 occurred in patients with a record of cancer. The cancer cohort were older and included more men and White racial groups. Regardless of cancer status, cardiovascular AAMR was higher in men, rural settings, and Black or African American races. Cardiovascular AAMR declined over time, with greater reduction in those with cancer (−51.6% vs −38.3%); the greatest reductions were in colorectal (−68.4%), prostate (−60.0%), and breast (−58.8%) cancers. Sex, race, and ethnic disparities reduced over time, with greater narrowing in the cancer cohort. There was increase in urban-rural disparities, which appeared greater in those with cancer.

Conclusions
While most social disparities narrowed over time, urban-rural disparities widened, with greater increase in those with cancer. Healthcare plans should incorporate strategies for reduction of health inequality equitable access to cardio-oncology services.

Citation

Raisi-Estabragh, Z., Kobo, O., López-Fernández, T., Qadir, H. A., Chew, N. W., Wojakowski, W., Abhishek, A., Miller, R. J., & Mamas, M. A. (2023). Social disparities in cardiovascular mortality of patients with cancer in the USA between 1999 and 2019. International Journal of Cardiology Cardiovascular Risk and Prevention, 19, Article 200218. https://doi.org/10.1016/j.ijcrp.2023.200218

• Journal Article Type: Article
• Acceptance Date: Sep 28, 2023
• Online Publication Date: Oct 3, 2023
• Publication Date: 2023-12
• Deposit Date: Oct 9, 2023
• Journal: International Journal of Cardiology Cardiovascular Risk and Prevention
• Electronic ISSN: 2772-4875
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 19
• Article Number: 200218
• DOI: https://doi.org/10.1016/j.ijcrp.2023.200218
• Public URL: https://keele-repository.worktribe.com/output/594570