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Identification of polymorphism at the glutathione s-transferase, GSTM3 locus: Evidence for linkage with GSTMI*A

Inskip, A; Elexperu-Camiruaga, J; Buxton, N; Dias, P S; MacIntosh, J; Campbell, D; Jones, P W; Yengi, L; Talbot, J A; Strange, R C; Fryer, A A

Authors

A Inskip

J Elexperu-Camiruaga

N Buxton

P S Dias

J MacIntosh

D Campbell

P W Jones

L Yengi

J A Talbot

R C Strange

A A Fryer



Contributors

A. Inskip
Other

J. Elexperu-Camiruaga
Other

N. Buxton
Other

P.S. Dias
Other

J. Maclntosh
Other

D. Campbell
Other

P.W. Jones
Other

L. Yengi
Other

J.A. Talbot
Other

R.C. Strange
Other

A.A. Fryer
Other

Abstract

Allelism in the glutathione S-transferase, GSTM3 gene has been identified using PCR with specific primers to exon 6/exon 7. Sequencing showed the mutant GSTM3*B allele to have a three-base deletion in intron 6 with a frequency of 0.158. The mutation generates a recognition sequence, 5′-AAGATA-3′, for the negative transcription factor YY1. GSTM3*B was significantly associated with GSTM1*A.

Citation

Inskip, A., Elexperu-Camiruaga, J., Buxton, N., Dias, P. S., MacIntosh, J., Campbell, D., …Fryer, A. A. (1995). Identification of polymorphism at the glutathione s-transferase, GSTM3 locus: Evidence for linkage with GSTMI*A. Biochemical Journal, 312(3), 713–716. https://doi.org/10.1042/bj3120713

Journal Article Type Article
Publication Date 1995-12
Deposit Date Feb 14, 2024
Journal Biochemical Journal
Print ISSN 0264-6021
Electronic ISSN 1470-8728
Publisher Portland Press
Peer Reviewed Peer Reviewed
Volume 312
Issue 3
Pages 713–716
DOI https://doi.org/10.1042/bj3120713
Publisher URL https://portlandpress.com/biochemj/article-abstract/312/3/713/38051/Identification-of-polymorphism-at-the-glutathione?redirectedFrom=fulltext