Aneurysmal bone cysts: A UK wide tumor center experience

Bavan, Luckshman; Eastley, Nicholas; Stevenson, Jonathan; Mifsud, Maximillian; Bayliss, Lee; Mahmoud, Shady; Baker, Gavin; Cusick, Laurence; Nail, Rebecca; Rankin, Kenneth; Crooks, Sophie; Cool, Paul; Williams, Derfel; Kandarakis, Georgios; Duncan, Roderick; Kothari, Alpesh

Abstract

Background and Objectives
This multicenter retrospective series of consecutive extra-spinal aneurysmal bone cysts aims to identify risk factors for treatment failure.

Methods
Aneurysmal bone cysts treated within seven collaborating centers with over 12-months follow-up were eligible for inclusion. Survival analyses were performed to identify variables associated with recurrence using log-rank tests and Cox proportional hazard regression.

Results
One hundred and fifteen (M:F 60:55) patients were included. Median age at presentation was 13 years and median follow-up was 27 months. Seventy-five patients underwent surgical curettage and 27% of these required further intervention for recurrence. Of the 30 patients who underwent biopsy with limited percutaneous curettage as initial procedure, 47% required no further treatment. Patients under 13 years (log-rank p = 0.006, HR 2.3, p = 0.011) and those treated who had limited curettage (log-rank p = 0.001, HR 2.7, p = 0.002) had a higher risk of recurrence/persistence.

Conclusions
There is a high risk of recurrence following surgical treatment for aneurysmal bone cysts and this risk is higher in young patients. However, the cyst heals in a substantial number of patients who have a limited curettage at the time of biopsy.

Citation

Bavan, L., Eastley, N., Stevenson, J., Mifsud, M., Bayliss, L., Mahmoud, S., Baker, G., Cusick, L., Nail, R., Rankin, K., Crooks, S., Cool, P., Williams, D., Kandarakis, G., Duncan, R., & Kothari, A. (in press). Aneurysmal bone cysts: A UK wide tumor center experience. Journal of Surgical Oncology, 129(3), 601-608. https://doi.org/10.1002/jso.27499

• Journal Article Type: Article
• Acceptance Date: Oct 15, 2023
• Online Publication Date: Nov 15, 2023
• Deposit Date: Nov 27, 2023
• Journal: Journal of Surgical Oncology
• Print ISSN: 0022-4790
• Electronic ISSN: 1096-9098
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 129
• Issue: 3
• Pages: 601-608
• DOI: https://doi.org/10.1002/jso.27499
• Keywords: Oncology, General Medicine, Surgery
• Public URL: https://keele-repository.worktribe.com/output/645903