Aneurysmal bone cysts: A UK wide tumor center experience

Bavan, Luckshman; Eastley, Nicholas; Stevenson, Jonathan; Mifsud, Maximillian; Bayliss, Lee; Mahmoud, Shady; Baker, Gavin; Cusick, Laurence; Nail, Rebecca; Rankin, Kenneth; Crooks, Sophie; Cool, Paul; Williams, Derfel; Kandarakis, Georgios; Duncan, Roderick; Kothari, Alpesh

Abstract

Background and Objectives
This multicenter retrospective series of consecutive extra-spinal aneurysmal bone cysts aims to identify risk factors for treatment failure.

Methods
Aneurysmal bone cysts treated within seven collaborating centers with over 12-months follow-up were eligible for inclusion. Survival analyses were performed to identify variables associated with recurrence using log-rank tests and Cox proportional hazard regression.

Results
One hundred and fifteen (M:F 60:55) patients were included. Median age at presentation was 13 years and median follow-up was 27 months. Seventy-five patients underwent surgical curettage and 27% of these required further intervention for recurrence. Of the 30 patients who underwent biopsy with limited percutaneous curettage as initial procedure, 47% required no further treatment. Patients under 13 years (log-rank p = 0.006, HR 2.3, p = 0.011) and those treated who had limited curettage (log-rank p = 0.001, HR 2.7, p = 0.002) had a higher risk of recurrence/persistence.

Conclusions
There is a high risk of recurrence following surgical treatment for aneurysmal bone cysts and this risk is higher in young patients. However, the cyst heals in a substantial number of patients who have a limited curettage at the time of biopsy.

• Journal Article Type: Article
• Acceptance Date: Oct 15, 2023
• Online Publication Date: Nov 15, 2023
• Deposit Date: Nov 27, 2023
• Journal: Journal of Surgical Oncology
• Print ISSN: 0022-4790
• Electronic ISSN: 1096-9098
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 129
• Issue: 3
• Pages: 601-608
• DOI: https://doi.org/10.1002/jso.27499
• Keywords: Oncology, General Medicine, Surgery