Access Site Practice and Procedural Outcomes in Relation to Clinical Presentation in 439,947 Patients Undergoing Percutaneous Coronary Intervention in the United Kingdom

Ratib, Karim; Mamas, Mamas A.; Anderson, Simon G.; Bhatia, Gurbir; Routledge, Helen; De Belder, Mark; Ludman, Peter F.; Fraser, Douglas; Nolan, James

Abstract

Objectives
This study sought to determine the relationships among access site practice, clinical presentation, and procedural outcomes in a large patient population.

Background
Transradial access (TRA) has been associated with improved patient outcomes in selected populations in randomized trials. It is unclear whether these outcomes are achievable in clinical practice.

Methods
Using the BCIS (British Cardiovascular Intervention Society) database, we investigated outcomes for percutaneous coronary intervention procedures undertaken between 2007 and 2012 according to access site practice. Patients were categorized as stable, non-ST-segment elevation acute coronary syndrome (NSTEACS) and ST-elevation acute coronary syndrome (STEACS). The impact of access site on 30-day mortality, major adverse cardiac events, bleeding, and arterial access site complications was studied.

Results
Data from 210,260 TRA and 229,687 transfemoral access procedures were analyzed. Following multivariate analysis, TRA was independently associated with a reduction in bleeding in all presenting syndromes (stable odds ratio [OR]: 0.24, p < 0.001; NSTEACS OR: 0.35, p < 0.001; STEACS OR: 0.47, p < 0.001) as well as access site complications (stable OR: 0.21, p < 0.001; NSTEACS OR: 0.19; STEACS OR: 0.16, p < 0.001). TRA was associated with reduced major adverse cardiac events only in patients with unstable syndromes (stable OR: 1.08, p = 0.25; NSTEACS OR: 0.72, p < 0.001; STEACS OR: 0.70, p < 0.001). TRA was associated with improved outcomes compared with a transfemoral access (TFA) with a vascular closure device in a propensity matched cohort.

Conclusions
In this large study, TRA is associated with reduced percutaneous coronary intervention–related complications in all patient groups and may reduce major adverse cardiac events and mortality in ACS patients. TRA is superior to transfemoral access with closure devices. Use of TRA may lead to important patient benefits in routine practice. TRA should be considered the preferred access site for percutaneous coronary intervention.

Citation

Ratib, K., Mamas, M. A., Anderson, S. G., Bhatia, G., Routledge, H., De Belder, M., …Nolan, J. (2015). Access Site Practice and Procedural Outcomes in Relation to Clinical Presentation in 439,947 Patients Undergoing Percutaneous Coronary Intervention in the United Kingdom. JACC: Cardiovascular Interventions, 8(1), 20-29. https://doi.org/10.1016/j.jcin.2014.06.026

• Journal Article Type: Article
• Acceptance Date: Jun 19, 2014
• Online Publication Date: Jan 20, 2015
• Publication Date: 2015-01
• Deposit Date: Nov 29, 2023
• Journal: JACC: Cardiovascular Interventions
• Print ISSN: 1936-8798
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 8
• Issue: 1
• Pages: 20-29
• DOI: https://doi.org/10.1016/j.jcin.2014.06.026
• Keywords: Cardiology and Cardiovascular Medicine
• Additional Information: This article is maintained by: Elsevier; Article Title: Access Site Practice and Procedural Outcomes in Relation to Clinical Presentation in 439,947 Patients Undergoing Percutaneous Coronary Intervention in the United Kingdom; Journal Title: JACC: Cardiovascular Interventions; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.jcin.2014.06.026; Content Type: article; Copyright: Copyright © 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.