Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin

Mycroft-West, Courtney J.; Su, Dunhao; Pagani, Isabel; Rudd, Timothy R.; Elli, Stefano; Guimond, Scott E.; Miller, Gavin; Meneghetti, Maria C. Z.; Nader, Helena B.; Li, Yong; Nunes, Quentin M.; Procter, Patricia; Mancini, Nicasio; Clementi, Massimo; Bisio, Antonella; Forsyth, Nicholas R.; Turnbull, Jeremy E.; Guerrini, Marco; Fernig, David G.; Vicenzi, Elisa; Yates, Edwin A.; Lima, Marcelo A.; Skidmore, Mark A.

doi:10.1101/2020.04.28.066761

Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin

Mycroft-West, Courtney J.; Su, Dunhao; Pagani, Isabel; Rudd, Timothy R.; Elli, Stefano; Guimond, Scott E.; Miller, Gavin; Meneghetti, Maria C. Z.; Nader, Helena B.; Li, Yong; Nunes, Quentin M.; Procter, Patricia; Mancini, Nicasio; Clementi, Massimo; Bisio, Antonella; Forsyth, Nicholas R.; Turnbull, Jeremy E.; Guerrini, Marco; Fernig, David G.; Vicenzi, Elisa; Yates, Edwin A.; Lima, Marcelo A.; Skidmore, Mark A.

Authors

Courtney J. Mycroft-West

Dunhao Su

Isabel Pagani

Timothy R. Rudd

Stefano Elli

Scott Guimond s.e.guimond@keele.ac.uk

Gavin Miller g.j.miller@keele.ac.uk

Maria C. Z. Meneghetti

Helena B. Nader

Yong Li

Quentin M. Nunes

Patricia Procter

Nicasio Mancini

Massimo Clementi

Antonella Bisio

Nicholas R. Forsyth

Jeremy E. Turnbull

Marco Guerrini

David G. Fernig

Elisa Vicenzi

Edwin A. Yates

Marcelo Andrade De Lima m.andrade.de.lima@keele.ac.uk

Mark Skidmore m.a.skidmore@keele.ac.uk

Citation

Mycroft-West, C. J., Su, D., Pagani, I., Rudd, T. R., Elli, S., Guimond, S. E., …Skidmore, M. A. Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin. [Preprint article]