Genetic Loss of miR-205 Causes Increased Mammary Gland Development

Cataldo, Alessandra; Cheung, Douglas G.; Hagan, John P.; Fassan, Matteo; Sandhu-Deol, Sukhinder; Croce, Carlo M.; Di Leva, Gianpiero; Iorio, Marilena V.

Abstract

MiRNAs play crucial roles in a broad spectrum of biological processes, both physiological and pathological. Different reports implicate miR-205 in the control of breast stem cell properties. Differential miR-205 expression has been observed in different stages of mammary gland development and maturation. However, a functional role in this process has not been clearly demonstrated. We generated an miR-205 knockout in the FVB/N mouse strain, which is viable and characterized by enhanced mammary gland development. Indeed, mammary glands of miR-205−/− female mice at different ages (1.5 and 5.5 months) show increased outgrowth and branching. This evidence is consistent with our previously reported data demonstrating the direct miR-205-mediated targeting of HER3, a master regulator of mammary gland development, and the oncosuppressive activity of this microRNA in different types of breast cancer.

Citation

Cataldo, A., Cheung, D. G., Hagan, J. P., Fassan, M., Sandhu-Deol, S., Croce, C. M., …Iorio, M. V. (in press). Genetic Loss of miR-205 Causes Increased Mammary Gland Development. Non-Coding RNA, 10(1), Article 4. https://doi.org/10.3390/ncrna10010004

• Journal Article Type: Article
• Acceptance Date: Dec 25, 2023
• Online Publication Date: Dec 31, 2023
• Deposit Date: Jan 15, 2024
• Publicly Available Date: Jan 15, 2024
• Journal: Non-Coding RNA
• Print ISSN: 2311-553X
• Publisher: MDPI
• Peer Reviewed: Peer Reviewed
• Volume: 10
• Issue: 1
• Article Number: 4
• DOI: https://doi.org/10.3390/ncrna10010004
• Keywords: Genetics, Molecular Biology, Biochemistry