Management of bile acid malabsorption using low-fat dietary interventions: a useful strategy applicable to some patients with diarrhoea-predominant irritable bowel syndrome?

Watson, Lorraine; Lalji, Amyn; Bodla, Shankar; Muls, Ann; Andreyev, H Jervoise N; Shaw, Clare

Abstract

This study evaluates the efficacy of low-fat dietary interventions in the management of gastrointestinal (GI) symptoms due to bile acid malabsorption. In total, 40 patients with GI symptoms and a 7-day 75selenium homocholic acid taurine (SeHCAT) scan result of <20%, were prospectively recruited and then advised regarding a low-fat dietary intervention. Before and after dietary intervention, patients rated their GI symptoms using a 10-point numerical scale, and recorded their intake in 7-day dietary diaries. After dietary intervention, the median scores for all GI symptoms decreased, with a significant reduction for urgency, bloating, lack of control, bowel frequency (p≥0.01). Mean dietary fat intake reduced to 42 g fat after intervention (p≥0.01). Low-fat dietary interventions in patients with a SeHCAT scan result of <20% leads to clinically important improvement in GI symptoms and should be widely used.

Citation

Watson, L., Lalji, A., Bodla, S., Muls, A., Andreyev, H. J. N., & Shaw, C. (2015). Management of bile acid malabsorption using low-fat dietary interventions: a useful strategy applicable to some patients with diarrhoea-predominant irritable bowel syndrome?. Clinical Medicine, 15(6), 536-540. https://doi.org/10.7861/clinmedicine.15-6-536

• Journal Article Type: Article
• Online Publication Date: Nov 30, 2015
• Publication Date: 2015-12
• Deposit Date: Jan 16, 2024
• Journal: Clinical Medicine
• Print ISSN: 1470-2118
• Electronic ISSN: 1473-4893
• Publisher: Royal College of Physicians
• Peer Reviewed: Peer Reviewed
• Volume: 15
• Issue: 6
• Pages: 536-540
• DOI: https://doi.org/10.7861/clinmedicine.15-6-536
• Keywords: General Medicine